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Table 4 Univariate and multivariate Cox regression analysis for miR-122-5p and miR-206 serum levels with progression-free survival as endpoint

From: Serum miR-122-5p and miR-206 expression: non-invasive prognostic biomarkers for renal cell carcinoma

  Univariate Analysis Model 1 Model 2 Model 3 Model 4
HR (95% CI) p value HR (95% CI) p value HR (95% CI) p value HR (95% CI) p value HR (95% CI) p value
miR-122-5p, >cut-off vs. <cut-off 3.63 1.42–9.32 0.007 2.11 0.73–6.11 0.169     2.34 0.77–7.11 0.132 1.62 0.45–5.84 0.455
miR-206, >cut-off vs. <cut-off 4.98 1.95–12.7 < 0.001 3.67 1.29–10.51 0.015 3.46 1.13–10.68 0.030     2.94 0.86–10.04 0.084
pT-stage, pT3–4 vs. pT1–2 4.14 1.59–10.79 0.004     1.85 0.58–5.92 0.300 2.68 0.88–8.21 0.082 1.94 0.60–6.29 0.269
pN-stage, pN1 vs. pN0 6.85 1.45–32.47 0.015     4.01 0.68–23.72 0.125 2.72 0.49–15.11 0.252 4.40 0.72–27.01 0.109
M-stage, cM1 vs. cM0 3.61 1.25–10.42 0.018     1.49 0.44–5.01 0.521 1.18 0.34–3.88 0.787 1.40 0.42–4.72 0.583
Fuhrman-Grading, G3 + 4 vs. G1 + 2 4.08 1.58–10.55 0.004     1.48 0.43–5.18 0.536 1.65 0.48–5.67 0.426 1.18 0.29–4.86 0.816
  1. Number of patients in analysis - 67, number of events (progression) - 18