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Fig. 2 | Clinical Epigenetics

Fig. 2

From: The signature of liver cancer in immune cells DNA methylation

Fig. 2

Differentially methylated CG sites at different stages of HCC and “cross-validation.” a Number of CG sites that are differentially methylated between different stages of HCC and healthy controls (p < 10−7) green: hypomethylated, red: hypermethylated. b Heat map presentation of hierarchical clustering of 69 people by 74 differentially methylated CGs between HCC stage 1 and control. c Heat map of hierarchical clustering of 69 people by 298 differentially methylated CGs between HCC stage 4 and control. d Ven diagram of the overlap between differentially methylated CG sites at different HCC stages (1–4). Significance was determined using Fisher exact test for all overlaps and all overlaps were highly significant (p < 1.7 × 10−321)

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