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Table 6 Pathway enrichment analyses for Gene Ontology (GO), KEGG, and Pathway Commons (PC) (separate pathways with BH-corrected p value < 0.1) based on significant findings from EWAS for change in lung function

From: Lung function discordance in monozygotic twins and associated differences in blood DNA methylation

Lung function measure

Database

Pathway name

No. of genes

Genes

Statistics

Log-ΔzFEV1-changeIP

No significant pathway enrichment results

  

Log-ΔzFVC-changeIP

No significant pathway enrichment results

  

ΔzFEV1/FVC-changeIP

GO

Transferase activity

2

GXYLT1 POLM

C = 1641; O = 2; E = 0.23; R = 8.67; rawP = 0.0133; adjP = 0.0399

  1. Bold indicates BH adjP < 0.05
  2. C the number of reference genes in the category; O: the number of genes in the gene set and also in the category, E the expected number in the category, R ratio of enrichment, rawP p value from hypergeometric test, adjP p value adjusted by the multiple test adjustment (BH)
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Clinical Epigenetics

ISSN: 1868-7083

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