Novel insights into epigenetic drivers of oropharyngeal squamous cell carcinoma: role of HPV and lifestyle factors

Table 4 Association of ncRNAs profiles and clinical outcome in OPSCC patients

NcRNA	Conclusion	Cohort	References
MiR-221	MiR-21 expression correlated with poor prognosis in HNSCC patients	147 HNSCC, including 31 OPSCC	[151]
Let-7d	Reduced expression of let-7d and miR-205 is a significant predictor of HNSCC progression independent of anatomical site, tumor stage, treatment, or HPV	104 HNSCC, including 32 OPSCC	[175]
MiR-205		104 HNSCC, including 32 OPSCC	[175]
MiR-107	Associated with overall survival (OS), independent of HPV status	88 OPSCC	[169]
MiR-151
MiR-492
MiR-20b	Associated with disease-free survival, independent of HPV status
MiR-107
MiR-151
MiR-182
MiR-361
MiR-151	Associated with distant metastasis, independent of HPV status
MiR-152
MiR-324-5p
MiR-361
MiR-492
MiR-9	Associated with OS in HPV-positive patients	150 OPSCC	[168]
MiR-18a
MiR-31
MiR-155
MiR-223
MiR-146	Single nucleotide polymorphisms in these miRNAs were associated with reduced and increased risk of OPSCC recurrence, respectively	1008 OPSCC	[176]
MiR-196		1008 OPSCC	[176]
MiR-193b-3p	Positively associated with OS	81 OPSCC obtained from “The Cancer Genome Atlas”, and 95 OPSCC patients included for validation	[177]
MiR-455-5p	Positively associated with OS
MiR-92a-3p	Negatively associated with OS
MiR-497-5p	Negatively associated with OS
PiR-30506	Associated with OS in HPV-positive patients	498 non-malignant and HNSCC tissues, including 66 OPSCC	[156]
PiR-35953
PiR-36715
PiR-36984
PiR-39592

ISSN: 1868-7083