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Table 4 Association of ncRNAs profiles and clinical outcome in OPSCC patients

From: Novel insights into epigenetic drivers of oropharyngeal squamous cell carcinoma: role of HPV and lifestyle factors

NcRNA Conclusion Cohort References
MiR-221 MiR-21 expression correlated with poor prognosis in HNSCC patients 147 HNSCC, including 31 OPSCC [151]
Let-7d Reduced expression of let-7d and miR-205 is a significant predictor of HNSCC progression independent of anatomical site, tumor stage, treatment, or HPV 104 HNSCC, including 32 OPSCC [175]
MiR-205
MiR-107 Associated with overall survival (OS), independent of HPV status 88 OPSCC [169]
MiR-151
MiR-492
MiR-20b Associated with disease-free survival, independent of HPV status
MiR-107
MiR-151
MiR-182
MiR-361
MiR-151 Associated with distant metastasis, independent of HPV status
MiR-152
MiR-324-5p
MiR-361
MiR-492
MiR-9 Associated with OS in HPV-positive patients 150 OPSCC [168]
MiR-18a
MiR-31
MiR-155
MiR-223
MiR-146 Single nucleotide polymorphisms in these miRNAs were associated with reduced and increased risk of OPSCC recurrence, respectively 1008 OPSCC [176]
MiR-196
MiR-193b-3p Positively associated with OS 81 OPSCC obtained from “The Cancer Genome Atlas”, and 95 OPSCC patients included for validation [177]
MiR-455-5p
MiR-92a-3p Negatively associated with OS
MiR-497-5p
PiR-30506 Associated with OS in HPV-positive patients 498 non-malignant and HNSCC tissues, including 66 OPSCC [156]
PiR-35953
PiR-36715
PiR-36984
PiR-39592