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Table 2 Association between average DNA methylation levels at AXL CpG sites and risk of asthma and related symptoms in childhood in the primary study population (N = 246)

From: Epigenetic regulation of AXL and risk of childhood asthma symptoms

  Average of near-TSS CpG sitesa Average of gene-body CpG sitesb Average of all 12 CpG sitesc
OR p OR p OR p
Ever MD-diagnosed asthma
 Overall 1.10 0.16 1.05 0.71 1.17 0.19
 By sex
  Boys 1.17 0.10 1.12 0.58 1.34 0.09
   Girls 1.03 0.79 1.00 1.00 1.02 0.90
 Interaction p value 0.33 0.69 0.28
Ever wheezing
 Overall 1.10 0.19 1.72 0.0002 1.46 0.005
By sex
 Boys 1.06 0.60 2.70 0.001 1.42 0.12
 Girls 1.12 0.20 1.51 0.01 1.48 0.02
 Interaction p value 0.69 0.08 0.88
Wheezing in the previous 12 months
 Overall 0.97 0.79 2.09 0.002 1.26 0.25
 By sex
  Boys 0.73 0.10 1.85 0.11 0.75 0.35
  Girls 1.16 0.31 2.20 0.005 1.88 0.02
  Interaction p value 0.05 0.70 0.03
Bronchitic symptoms in the previous 12 months
 Overall 0.99 0.90 1.23 0.14 1.04 0.74
 By sex
  Boys 0.94 0.51 1.18 0.46 0.92 0.64
  Girls 1.05 0.63 1.26 0.19 1.18 0.35
  Interaction p value 0.41 0.82 0.32
  1. The primary study population (N = 246) is adjusted for child’s age, sex, ethnicity, methylation plate and city of residence at study recruitment; additionally adjusted for ever had MD-diagnosed asthma for wheezing and bronchitic outcomes. Odds ratios are presented for an increase in 1% of DNA methylation level at birth. For all comparisons, the reference group is children not having the corresponding outcome. Significant p values (< 0.05) are marked in italics
  2. TSS transcription start site
  3. aAverage of cg10564498, cg03247049, cg12722469, cg02372201, cg19848291 and cg14892768
  4. bAverage of cg27579501, cg00360107, cg19270050, cg24901063 and cg26521562
  5. cAverage of all 12 CpG sites