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Table 3 KRAS and BRAF mutations, CpG island methylator phenotype (CIMP), and ZNF331 methylation status in colorectal cancer patients

From: Methylation of ZNF331 is an independent prognostic marker of colorectal cancer and promotes colorectal cancer growth

Marker genes Number ZNF331 methylation status p value
Methylated Unmethylated
KRAS mutation
 Wide type 94 60 34 0.437
 Mutation 42 30 12  
BRAF 600E mutation
 Wide type 133 87 46 1.000
 Mutation 4 3 1  
CIMP
 CIMP-high 15 12 3 0.260
 CIMP-low 121 77 44  
CACNA1G
 Methylated 29 22 7 0.271
 Unmethylated 107 67 40  
IGF2
 Methylated 34 25 9 0.301
 Unmethylated 102 64 38  
MLH1
 Methylated 21 13 8 0.804
 Unmethylated 115 76 39  
RUNX3
 Methylated 14 11 3 0.379
 Unmethylated 122 78 44