Table 3 KRAS and BRAF mutations, CpG island methylator phenotype (CIMP), and ZNF331 methylation status in colorectal cancer patients
Marker genes | Number | ZNF331 methylation status | p value | |
|---|---|---|---|---|
Methylated | Unmethylated | |||
KRAS mutation | ||||
Wide type | 94 | 60 | 34 | 0.437 |
Mutation | 42 | 30 | 12 | |
BRAF 600E mutation | ||||
Wide type | 133 | 87 | 46 | 1.000 |
Mutation | 4 | 3 | 1 | |
CIMP | ||||
CIMP-high | 15 | 12 | 3 | 0.260 |
CIMP-low | 121 | 77 | 44 | |
CACNA1G | ||||
Methylated | 29 | 22 | 7 | 0.271 |
Unmethylated | 107 | 67 | 40 | |
IGF2 | ||||
Methylated | 34 | 25 | 9 | 0.301 |
Unmethylated | 102 | 64 | 38 | |
MLH1 | ||||
Methylated | 21 | 13 | 8 | 0.804 |
Unmethylated | 115 | 76 | 39 | |
RUNX3 | ||||
Methylated | 14 | 11 | 3 | 0.379 |
Unmethylated | 122 | 78 | 44 | |