Skip to main content

Table 3 Summary of the effects of PAE on half-lives of histones in frontal cortex and hypothalamus of rat brain

From: Turnover of histones and histone variants in postnatal rat brain: effects of alcohol exposure

  Half-life in frontal cortex (d) Half-life in Hypothalamus (d)
Histone PF AF PF AF
H2Aun 5.9 ± 0.3 9.7 ± 0.8** 7.2 ± 0.4 13.1 ± 1.3**
H2AK120meK126ac 6.9 ± 1.1 11.7 ± 3.6 6.8 ± 0.5 10.7 ± 2.3**
H2Bun 27.4 ± 8.9 41.5 ± 15.2 20.5 ± 0.2 65.5 ± 12.1***
H2BK9ac 14.2 ± 4.4 12.8 ± 5.8 9.4 ± 1.5## 20.7 ± 2.8** #
H3un 11.0 ± 0.9 14.6 ± 1.1** 14.3 ± 0.9 20.5 ± 1.0**
H3K1ac 7.5 ± 0.4## 8.7 ± 0.4## 8.9 ± 0.2# 17.5 ± 5.9*
H3K9 10.0 ± 0.6 20.2 ± 2.9 19.8 ± 3.0 33.2 ± 1.7
H3K9me2 25.2 ± 6.7 21.4 ± 1.3 18.2 ± 2.8 22.3 ± 3.1
H3K9me3 23.1 ± 5.8 46.1 ± 15.8 38.7 ± 5.7a 69.8 ± 4***
H3K9ac 6.4 ± 0.4# 12.1 ± 3.3 10.5 ± 2.0# 19.9 ± 6.7
H4un 16.2 ± 1.7 29.8 ± 6.3** 28.4 ± 3.4 40.3 ± 1.1*
H4K5acK9acK13ac 8.2 ± 0.7## 8.5 ± 0.1### 11.5 ± 2.9# 14.8 ± 2.6#
H1 10.0 ± 1.3 20.4 ± 5.9*** 12.3 ± 1.2 19.8 ± 1.2*
H1.1 3.9 ± 0.7 7.9 ± 0.7* 5.7 ± 0.7 10.8 ± 2.2*
H1.4 12.7 ± 2.8 13.9 ± 1.5 11.1 ± 0.6 18.9 ± 0.9***
H1.5 11.3 ± 1.8 20.2 ± 8.2 10.1 ± 0.6 14.5 ± 0.3*
H3.3 4.2 ± 0.6 7.8 ± 0.5** 9.3 ± 2.0 11.3 ± 3.5
H2Ax 12.1 ± 1.6 14.3 ± 1.5 15.1 ± 5.0 39.6 ± 9.1*
H2Az 5.1 ± 0.9 8.6 ± 2.0** 6.0 ± 0.5 8.2 ± 0.5*
  1. Half-lives are calculated from FSR data as described in the “Methods” section. d day, Un unmodified, Ac: acetylated, me2 di-methylation, me3 tri-methylation. Data are shown as mean ± SE, n = 4 per group, *p < 0.05, **p < 0.01, ***p < 0.001, AF vs PF, #p < 0.05, ##p < 0.01, ###p < 0.001 Nac vs Ac