Table 3 Summary of the effects of PAE on half-lives of histones in frontal cortex and hypothalamus of rat brain
From: Turnover of histones and histone variants in postnatal rat brain: effects of alcohol exposure
Half-life in frontal cortex (d) | Half-life in Hypothalamus (d) | |||
|---|---|---|---|---|
Histone | PF | AF | PF | AF |
H2Aun | 5.9 ± 0.3 | 9.7 ± 0.8** | 7.2 ± 0.4 | 13.1 ± 1.3** |
H2AK120meK126ac | 6.9 ± 1.1 | 11.7 ± 3.6 | 6.8 ± 0.5 | 10.7 ± 2.3** |
H2Bun | 27.4 ± 8.9 | 41.5 ± 15.2 | 20.5 ± 0.2 | 65.5 ± 12.1*** |
H2BK9ac | 14.2 ± 4.4 | 12.8 ± 5.8 | 9.4 ± 1.5## | 20.7 ± 2.8** # |
H3un | 11.0 ± 0.9 | 14.6 ± 1.1** | 14.3 ± 0.9 | 20.5 ± 1.0** |
H3K1ac | 7.5 ± 0.4## | 8.7 ± 0.4## | 8.9 ± 0.2# | 17.5 ± 5.9* |
H3K9 | 10.0 ± 0.6 | 20.2 ± 2.9 | 19.8 ± 3.0 | 33.2 ± 1.7 |
H3K9me2 | 25.2 ± 6.7 | 21.4 ± 1.3 | 18.2 ± 2.8 | 22.3 ± 3.1 |
H3K9me3 | 23.1 ± 5.8 | 46.1 ± 15.8 | 38.7 ± 5.7a | 69.8 ± 4*** |
H3K9ac | 6.4 ± 0.4# | 12.1 ± 3.3 | 10.5 ± 2.0# | 19.9 ± 6.7 |
H4un | 16.2 ± 1.7 | 29.8 ± 6.3** | 28.4 ± 3.4 | 40.3 ± 1.1* |
H4K5acK9acK13ac | 8.2 ± 0.7## | 8.5 ± 0.1### | 11.5 ± 2.9# | 14.8 ± 2.6# |
H1 | 10.0 ± 1.3 | 20.4 ± 5.9*** | 12.3 ± 1.2 | 19.8 ± 1.2* |
H1.1 | 3.9 ± 0.7 | 7.9 ± 0.7* | 5.7 ± 0.7 | 10.8 ± 2.2* |
H1.4 | 12.7 ± 2.8 | 13.9 ± 1.5 | 11.1 ± 0.6 | 18.9 ± 0.9*** |
H1.5 | 11.3 ± 1.8 | 20.2 ± 8.2 | 10.1 ± 0.6 | 14.5 ± 0.3* |
H3.3 | 4.2 ± 0.6 | 7.8 ± 0.5** | 9.3 ± 2.0 | 11.3 ± 3.5 |
H2Ax | 12.1 ± 1.6 | 14.3 ± 1.5 | 15.1 ± 5.0 | 39.6 ± 9.1* |
H2Az | 5.1 ± 0.9 | 8.6 ± 2.0** | 6.0 ± 0.5 | 8.2 ± 0.5* |