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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Silencing HOXD10 by promoter region hypermethylation activates ERK signaling in hepatocellular carcinoma

Fig. 6

HOXD10 interacts with IGFBP3 and inhibits ERK1/2 phosphorylation in HCC. a ChIP results show that HOXD10 binds to the promoter region of IGFBP3. b Western blots show the levels of HOXD10, IGFBP3, ERK1/2 and p-ERK1/2 in SMMC7721 and Huh7 cells. β-actin: internal control. −: no serum stimulation. +: serum stimulation. c The expression levels of HOXD10 after knockdown by siRNA in Huh1 cells. HOXD10-Si: siRNA, NC: negative control. d The levels of HOXD10, IGFBP3, ERK1/2, and p-ERK1/2 were detected by western blot after knockdown of HOXD10 in Huh1 cells. β-actin: internal control. −: no serum stimulation. +: serum stimulation

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Clinical Epigenetics

ISSN: 1868-7083

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