Table 4 Ingenuity Pathway Analysis of differentially methylated genes
| Â | p value | Overlap n (%) |
|---|---|---|
Arm A top canonical pathways | ||
 Neuropathic pain signaling in doral horn neurons | 7.5e−12 | 35/100 (35.0%) |
 Glutamate receptor signaling | 2.45e−11 | 25/57 (43.9%) |
 Amyotrophic lateral sclerosis signaling | 2.05e−09 | 31/98 (31.6%) |
 Synaptic long-term potentiation | 1.00e−06 | 30/119 (25.2% |
 Hepatic fibrosis/hepatic stellate cell activation | 1.01e−06 | 40/183 (21.9%) |
Arm B top canonical pathways | ||
 Transcriptional regulatory network in embryonic stem cells | 2.68e−04 | 4/40 (10.0%) |
 Thrombin signaling | 7.94e−04 | 7/191 (3.7%) |
 GPCR-mediated integration of enteroendocrine signaling Exemplified by an L Cell | 2.36e−03 | 4/71 (5.6%) |
 Signaling by Rho Family GTPases | 2.54e−03 | 7/234 (3.0%) |
 CXCR4 signaling | 7.03e−03 | 5/152 (3.3%) |