Fig. 4

Integrated Genomic Viewer snapshot of differentially methylated genes affected by hypomethylation in response to decitabine therapy. Vertical heatmaps represent significantly differentially methylated (p value < 0.05) probes in the six genes illustrated. Each row on the heatmap represents a unique sample. Many more probes were differentially methylated in Arm A (decitabine+ chemotherapy) compared with Arm B (chemotherapy alone) for the probes shown. Hypomethylation (green) in response to decitabine (Arm A) is evident in end of induction recovery marrows (week 3) compared with diagnostic marrows (screen). Array avg β values are represented in the heatmap. Scale ranges from 0 to 1, where 0 is unmethylated (green) and 1 is fully methylated (red). Tracks shown gene, CpG 450 K probe, and CpG island