Fig. 2
From: Epigenome alterations in aortic valve stenosis and its related left ventricular hypertrophy
Epigenetic mechanisms currently associated with aortic VICs. ALP alkaline phosphatase, liver/bone/kidney, ALOX5 arachidonate 5-lipoxygenase, AVICs aortic valve interstitial cells, BAV bicuspid aortic valve, BGLAP/OCN bone gamma-carboxyglutamate protein/osteocalcin, BMP2 bone morphogenetic protein 2, BMPR2 bone morphogenetic protein receptor type 2, β-catenin CTNNB1/catenin (cadherin-associated protein), beta 1, CASP3 Caspase 3, apoptosis-related cysteine peptidase, DLX5 distal-less homeobox 5, DNMT3b DNA (Cytosine-5-)-methyltransferase 3 beta, ERK1 extracellular signal-regulated kinase 1/MAPK3 mitogen-activated protein kinase 3, ERK2 extracellular signal-regulated kinase 2/MAPK1 mitogen-activated protein kinase 1, H19 imprinted maternally expressed non-protein coding transcript, IKKβ inhibitor of kappa light polypeptide gene enhancer in b-cells, kinase beta, NF-Kb nuclear factor kappa b signaling pathway, IGF-1 insulin-like growth factor 1, ILα interleukin alpha, ILβ interleukin beta, IL8 interleukin 8, NOTCH1 notch homolog 1, translocation-associated (drosophila), JAG2 jagged, MMP1 matrix metallopeptidase 1, MMP2 matrix metallopeptidase 2, MMP9 matrix metallopeptidase 9, MMP14 matrix metallopeptidase 14, MMP16 matrix metallopeptidase 16, OSX SP7 transcription factor/osterix, p65 RELA/RELA proto-oncogene, NF-KB subunit, RUNX2 runt related transcription factor 2, SMAD1 SMAD family member 1, SMAD3 SMAD family member 3, SMAD5 SMAD family member 5, SMAD7 SMAD family member 7, SPP1 secreted phosphoprotein 1/OPN osteopontin/BNSP bone sialoprotein I, TGFβ1 transforming growth factor beta 1, TGFBR2 transforming growth factor beta receptor 2, WNT5a Wnt family member 5a