|
Group
|
AUC (95% CI)
|
Best cutoff
|
Sensitivity
|
Specificity
|
P value
|
|---|
|
MiR-122
|
|
OBI vs HC
|
0.66 (0.58–0.73)
|
2.39
|
0.79
|
0.55
|
< 0.001
|
|
OBI vs ASC
|
0.75 (0.69–0.82)
|
2.95
|
0.59
|
0.82
|
< 0.001
|
|
OBI vs CHB
|
0.88 (0.83–0.92)
|
2.95
|
0.86
|
0.83
|
< 0.001
|
|
MiR-130a
|
|
OBI vs HC
|
0.91 (0.87–0.96)
|
2.32
|
0.88
|
0.89
|
< 0.001
|
|
OBI vs ASC
|
0.75 (0.69–0.82)
|
2.95
|
0.59
|
0.82
|
< 0.001
|
|
OBI vs CHB
|
0.67 (0.60–0.74)
|
3.03
|
0.60
|
0.73
|
< 0.001
|
|
MiR-122 + MiR-130a
|
|
OBI vs HC
|
0.93 (0.90–0.97)
|
0.43
|
0.89
|
0.88
|
< 0.001
|
|
OBI vs ASC
|
0.87 (0.82–0.92)
|
0.35
|
0.94
|
0.68
|
< 0.001
|
|
OBI vs CHB
|
0.90 (0.85–0.94)
|
0.39
|
0.93
|
0.78
|
< 0.001
|
-
HC healthy controls, OBI occult hepatitis B virus infection, ASC asymptomatic HBsAg carriers, CHB chronic hepatitis B
