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Table 3 Comparison of ROC curves for serum miRNA-122, miRNA-130a, and combination of miR-122 and miR-130a

From: Identification and characterization of interferon signaling-related microRNAs in occult hepatitis B virus infection

Group AUC (95% CI) Best cutoff Sensitivity Specificity P value
MiR-122
 OBI vs HC 0.66 (0.58–0.73) 2.39 0.79 0.55 < 0.001
 OBI vs ASC 0.75 (0.69–0.82) 2.95 0.59 0.82 < 0.001
 OBI vs CHB 0.88 (0.83–0.92) 2.95 0.86 0.83 < 0.001
MiR-130a
 OBI vs HC 0.91 (0.87–0.96) 2.32 0.88 0.89 < 0.001
 OBI vs ASC 0.75 (0.69–0.82) 2.95 0.59 0.82 < 0.001
 OBI vs CHB 0.67 (0.60–0.74) 3.03 0.60 0.73 < 0.001
MiR-122 + MiR-130a
 OBI vs HC 0.93 (0.90–0.97) 0.43 0.89 0.88 < 0.001
 OBI vs ASC 0.87 (0.82–0.92) 0.35 0.94 0.68 < 0.001
 OBI vs CHB 0.90 (0.85–0.94) 0.39 0.93 0.78 < 0.001
  1. HC healthy controls, OBI occult hepatitis B virus infection, ASC asymptomatic HBsAg carriers, CHB chronic hepatitis B