Identification and characterization of interferon signaling-related microRNAs in occult hepatitis B virus infection

Table 3 Comparison of ROC curves for serum miRNA-122, miRNA-130a, and combination of miR-122 and miR-130a

Group	AUC (95% CI)	Best cutoff	Sensitivity	Specificity	P value
MiR-122
OBI vs HC	0.66 (0.58–0.73)	2.39	0.79	0.55	< 0.001
OBI vs ASC	0.75 (0.69–0.82)	2.95	0.59	0.82	< 0.001
OBI vs CHB	0.88 (0.83–0.92)	2.95	0.86	0.83	< 0.001
MiR-130a
OBI vs HC	0.91 (0.87–0.96)	2.32	0.88	0.89	< 0.001
OBI vs ASC	0.75 (0.69–0.82)	2.95	0.59	0.82	< 0.001
OBI vs CHB	0.67 (0.60–0.74)	3.03	0.60	0.73	< 0.001
MiR-122 + MiR-130a
OBI vs HC	0.93 (0.90–0.97)	0.43	0.89	0.88	< 0.001
OBI vs ASC	0.87 (0.82–0.92)	0.35	0.94	0.68	< 0.001
OBI vs CHB	0.90 (0.85–0.94)	0.39	0.93	0.78	< 0.001

HC healthy controls, OBI occult hepatitis B virus infection, ASC asymptomatic HBsAg carriers, CHB chronic hepatitis B

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