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Table 6 Replicated differentially methylated positions (DMPs) associated with WC and abdominal obesity reported by previous EWAS

From: An epigenome-wide association study in whole blood of measures of adiposity among Ghanaians: the RODAM study

      WC Abdominal obesity
CpG site CHR Position Nearest gene (distance)a Featureb Beta differencec p valued FDRd Beta differencec p valued FDRd
cg00574958 11 68607622 CPT1A 5′ UTR − 0.0007 1.02E − 08 9.87E − 06 −0.0135 1.55E − 08 1.49E − 05
cg04927537 17 76976091 LGALS3BP TSS200 0.0013 6.74E − 08 3.26E − 05 0.0195 4.44E − 05 1.07E − 02
cg25178683 17 76976267 LGALS3BP TSS1500 0.0011 3.96E − 07 1.28E − 04 0.0136 1.54E − 05 7.22E − 03
cg07504977 10 102131012 LINC00263 (− 2321) IGR 0.0010 1.60E − 05 3.87E − 03 0.0240 2.24E − 05 7.22E − 03
cg18335991 15 74724562 SEMA7A Body 0.0009 2.22E − 05 4.30E − 03 0.0147 3.75E − 04 7.24E − 02
cg27243685 21 43642366 ABCG1 Body 0.0004 7.58E − 05 1.22E − 02 0.0037 1.72E − 02 3.77E − 01
cg10927968 11 1807333 CTSD IGR 0.0007 9.42E − 05 1.30E − 02 0.0082 1.27E − 02 3.77E − 01
cg06500161 21 43656587 ABCG1 Body 0.0003 2.15E − 04 2.60E − 02 0.0033 3.47E − 03 2.76E − 01
cg13123009 6 31681882 LY6G6E TSS200 0.0004 3.22E − 04 3.46E − 02 0.0074 3.65E − 03 2.76E − 01
cg17439800 1 208056493 CD34 IGR 0.0006 5.09E − 04 4.92E − 02 0.0205 5.83E − 04 9.39E − 02
  1. aCpGs are located in the gene if no distance is indicated. Distance is expressed in kilobase
  2. bBased on manifest feature annotation Illumina. IGR, intergenic region
  3. cNegative beta values indicate lower DNA methylation (hypo-methylation) in cases compared with controls
  4. d p values and FDR corresponding to M values. Table is sorted on WC associated p values. All significant hits for both outcomes are included
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