An epigenome-wide association study in whole blood of measures of adiposity among Ghanaians: the RODAM study

Karlijn A.C. Meeks; Peter Henneman; Andrea Venema; Tom Burr; Cecilia Galbete; Ina Danquah; Matthias B. Schulze; Frank P. Mockenhaupt; Ellis Owusu-Dabo; Charles N. Rotimi; Juliet Addo; Liam Smeeth; Silver Bahendeka; Joachim Spranger; Marcel M.A.M. Mannens; Mohammad H. Zafarmand; Charles Agyemang; Adebowale Adeyemo

doi:10.1186/s13148-017-0403-x

Table 5 Replicated differentially methylated positions (DMPs) associated with BMI and obesity reported by previous EWAS

From: An epigenome-wide association study in whole blood of measures of adiposity among Ghanaians: the RODAM study

					BMI			Obesity
CpG site	CHR	Position	Nearest gene (distance)^a	Feature^b	Beta difference^c	p value^d	FDR^d	Beta difference^c	p value^d	FDR^d
cg00574958	11	68607622	CPT1A	5′ UTR	− 0.0014	1.47E − 07	1.42E − 04	− 0.0189	2.58E − 10	2.49E − 07
cg25178683	17	76976267	LGALS3BP	TSS1500	0.0019	1.20E − 06	4.62E − 04	0.0195	8.51E − 05	2.74E − 02
cg04927537	17	76976091	LGALS3BP	TSS200	0.0026	1.43E − 06	4.62E − 04	0.0286	6.85E − 06	3.31E − 03
cg10927968	11	1807333	CTSD (33351)	IGR	0.0015	2.58E − 05	6.24E − 03	0.0135	2.71E − 04	4.15E − 02
cg17320136	5	10567905	ANKRD33B	Body	0.0015	7.47E − 05	1.44E − 02	0.0109	9.60E − 04	1.03E − 01
cg03345232	14	92981121	RIN3	Body	0.0022	1.29E − 04	1.78E − 02	0.0193	2.08E − 03	1.66E − 01
cg08726900	16	89550474	ANKRD11	5′ UTR	− 0.0029	1.40E − 04	1.78E − 02	− 0.0237	3.85E − 03	2.33E − 01
cg11024682	17	17730094	SREBF1	Body	0.0009	1.52E − 04	1.78E − 02	0.0119	1.80E − 04	3.47E − 02
cg15871086	18	56526595	ZNF532 (− 3466)	IGR	0.0011	1.66E − 04	1.78E − 02	0.0115	1.78E − 04	3.47E − 02
cg18335991	15	74724562	SEMA7A	Body	0.0019	2.19E − 04	2.12E − 02	0.0175	2.24E − 03	1.66E − 01
cg07504977	10	102131012	LINC00263 (− 2321)	IGR	0.0018	2.57E − 04	2.26E − 02	0.0191	8.32E − 04	1.01E − 01
cg27243685	21	43642366	ABCG1	Body	0.0005	4.50E − 04	3.46E − 02	0.0054	2.41E − 03	1.66E − 01
cg17439800	1	208056493	CD34 (− 3390)	IGR	0.0016	4.65E − 04	3.46E − 02	0.0123	2.06E − 02	5.38E − 01
cg06500161	21	43656587	ABCG1	Body	0.0005	5.46E − 04	3.77E − 02	0.0077	3.00E − 04	4.15E − 02
cg03546163	6	35654363	FKBP5	5′ UTR	0.0019	6.96E − 04	4.49E − 02	0.0181	4.18E − 03	2.38E − 01

^aCpGs are located in the gene if no distance is indicated. Distance is expressed in kilobase
^bBased on manifest feature annotation Illumina. IGR, intergenic region
^cNegative beta values indicate lower DNA methylation (hypo-methylation) in cases compared with controls
^d p values and FDR corresponding to M values. Table is sorted on BMI associated p values. All significant hits for both outcomes are included

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