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Table 5 Replicated differentially methylated positions (DMPs) associated with BMI and obesity reported by previous EWAS

From: An epigenome-wide association study in whole blood of measures of adiposity among Ghanaians: the RODAM study

      BMI Obesity
CpG site CHR Position Nearest gene (distance)a Featureb Beta differencec p valued FDRd Beta differencec p valued FDRd
cg00574958 11 68607622 CPT1A 5′ UTR − 0.0014 1.47E − 07 1.42E − 04 − 0.0189 2.58E − 10 2.49E − 07
cg25178683 17 76976267 LGALS3BP TSS1500 0.0019 1.20E − 06 4.62E − 04 0.0195 8.51E − 05 2.74E − 02
cg04927537 17 76976091 LGALS3BP TSS200 0.0026 1.43E − 06 4.62E − 04 0.0286 6.85E − 06 3.31E − 03
cg10927968 11 1807333 CTSD (33351) IGR 0.0015 2.58E − 05 6.24E − 03 0.0135 2.71E − 04 4.15E − 02
cg17320136 5 10567905 ANKRD33B Body 0.0015 7.47E − 05 1.44E − 02 0.0109 9.60E − 04 1.03E − 01
cg03345232 14 92981121 RIN3 Body 0.0022 1.29E − 04 1.78E − 02 0.0193 2.08E − 03 1.66E − 01
cg08726900 16 89550474 ANKRD11 5′ UTR − 0.0029 1.40E − 04 1.78E − 02 − 0.0237 3.85E − 03 2.33E − 01
cg11024682 17 17730094 SREBF1 Body 0.0009 1.52E − 04 1.78E − 02 0.0119 1.80E − 04 3.47E − 02
cg15871086 18 56526595 ZNF532 (− 3466) IGR 0.0011 1.66E − 04 1.78E − 02 0.0115 1.78E − 04 3.47E − 02
cg18335991 15 74724562 SEMA7A Body 0.0019 2.19E − 04 2.12E − 02 0.0175 2.24E − 03 1.66E − 01
cg07504977 10 102131012 LINC00263 (− 2321) IGR 0.0018 2.57E − 04 2.26E − 02 0.0191 8.32E − 04 1.01E − 01
cg27243685 21 43642366 ABCG1 Body 0.0005 4.50E − 04 3.46E − 02 0.0054 2.41E − 03 1.66E − 01
cg17439800 1 208056493 CD34 (− 3390) IGR 0.0016 4.65E − 04 3.46E − 02 0.0123 2.06E − 02 5.38E − 01
cg06500161 21 43656587 ABCG1 Body 0.0005 5.46E − 04 3.77E − 02 0.0077 3.00E − 04 4.15E − 02
cg03546163 6 35654363 FKBP5 5′ UTR 0.0019 6.96E − 04 4.49E − 02 0.0181 4.18E − 03 2.38E − 01
  1. aCpGs are located in the gene if no distance is indicated. Distance is expressed in kilobase
  2. bBased on manifest feature annotation Illumina. IGR, intergenic region
  3. cNegative beta values indicate lower DNA methylation (hypo-methylation) in cases compared with controls
  4. d p values and FDR corresponding to M values. Table is sorted on BMI associated p values. All significant hits for both outcomes are included