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Table 5 Replicated differentially methylated positions (DMPs) associated with BMI and obesity reported by previous EWAS

From: An epigenome-wide association study in whole blood of measures of adiposity among Ghanaians: the RODAM study

     

BMI

Obesity

CpG site

CHR

Position

Nearest gene (distance)a

Featureb

Beta differencec

p valued

FDRd

Beta differencec

p valued

FDRd

cg00574958

11

68607622

CPT1A

5′ UTR

− 0.0014

1.47E − 07

1.42E − 04

− 0.0189

2.58E − 10

2.49E − 07

cg25178683

17

76976267

LGALS3BP

TSS1500

0.0019

1.20E − 06

4.62E − 04

0.0195

8.51E − 05

2.74E − 02

cg04927537

17

76976091

LGALS3BP

TSS200

0.0026

1.43E − 06

4.62E − 04

0.0286

6.85E − 06

3.31E − 03

cg10927968

11

1807333

CTSD (33351)

IGR

0.0015

2.58E − 05

6.24E − 03

0.0135

2.71E − 04

4.15E − 02

cg17320136

5

10567905

ANKRD33B

Body

0.0015

7.47E − 05

1.44E − 02

0.0109

9.60E − 04

1.03E − 01

cg03345232

14

92981121

RIN3

Body

0.0022

1.29E − 04

1.78E − 02

0.0193

2.08E − 03

1.66E − 01

cg08726900

16

89550474

ANKRD11

5′ UTR

− 0.0029

1.40E − 04

1.78E − 02

− 0.0237

3.85E − 03

2.33E − 01

cg11024682

17

17730094

SREBF1

Body

0.0009

1.52E − 04

1.78E − 02

0.0119

1.80E − 04

3.47E − 02

cg15871086

18

56526595

ZNF532 (− 3466)

IGR

0.0011

1.66E − 04

1.78E − 02

0.0115

1.78E − 04

3.47E − 02

cg18335991

15

74724562

SEMA7A

Body

0.0019

2.19E − 04

2.12E − 02

0.0175

2.24E − 03

1.66E − 01

cg07504977

10

102131012

LINC00263 (− 2321)

IGR

0.0018

2.57E − 04

2.26E − 02

0.0191

8.32E − 04

1.01E − 01

cg27243685

21

43642366

ABCG1

Body

0.0005

4.50E − 04

3.46E − 02

0.0054

2.41E − 03

1.66E − 01

cg17439800

1

208056493

CD34 (− 3390)

IGR

0.0016

4.65E − 04

3.46E − 02

0.0123

2.06E − 02

5.38E − 01

cg06500161

21

43656587

ABCG1

Body

0.0005

5.46E − 04

3.77E − 02

0.0077

3.00E − 04

4.15E − 02

cg03546163

6

35654363

FKBP5

5′ UTR

0.0019

6.96E − 04

4.49E − 02

0.0181

4.18E − 03

2.38E − 01

  1. aCpGs are located in the gene if no distance is indicated. Distance is expressed in kilobase
  2. bBased on manifest feature annotation Illumina. IGR, intergenic region
  3. cNegative beta values indicate lower DNA methylation (hypo-methylation) in cases compared with controls
  4. d p values and FDR corresponding to M values. Table is sorted on BMI associated p values. All significant hits for both outcomes are included
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Clinical Epigenetics

ISSN: 1868-7083

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