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Table 3 Correlations between DNA methylation of metformin transporter genes in human liver and metabolic phenotypes including fasting glucose and BMI with P values < 0.05 in subjects from the Kuopio Obesity Surgery Study (n = 95)

From: Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver

Probe ID Chr. Position Gene region B (P value) q value
GLUCOSE (mmol/L)a
SLC22A1
 cg24864413 6 160542732 TSS200 0.73 (0.001) 0.013
 cg22416916 6 160542770 TSS200 0.52 (0.011) 0.065
 cg13466809 6 160542944 1stExon;5’UTR 0.39 (0.027) 0.070
 cg27292431 6 160543261 1stExon 0.61 (0.020) 0.065
 cg07558837 6 160555312 Body 0.22 (0.015) 0.065
 Average DNA methylation (13 CpG sites) 0.33 (0.002)  
 DNA methylation promoter region: TSS1500 and TSS200 (4 CpG sites) 0.60 (0.007)  
SLC22A3
 cg06295784 6 160771074 Body 0.62 (0.004) 0.046
 cg07883823 6 160769116 TSS1500 0.30 (0.002) 0.046
 cg11696576 6 160815734 Body 0.57 (0.025) 0.143
 cg22117918 6 160769114 TSS1500 0.16 (0.043) 0.198
 cg25313204 6 160768801 TSS1500 0.65 (0.008) 0.061
 Average DNA methylation (23 CpG sites) 0.14 (0.056)  
 DNA methylation promoter region: TSS1500 and TSS200 (5 CpG sites) 0.21 (0.008)  
SLC47A1
 cg01530032 17 19435805 TSS1500 0.91 (0.002) 0.016
 cg07829432 17 19437013 TSS200 0.13 (0.001) 0.012
 cg08895056 17 19438253 Body 0.49 (0.031) 0.136
 cg11784214 17 19479935 Body 0.19 (0.047) 0.161
 cg12550399 17 19482275 3′ UTR 1.14 (0.001) 0.012
 cg15014549 17 19437003 TSS200 0.06 (0.034) 0.136
 cg24151087 17 19450271 Body 0.24 (0.020) 0.120
 Average DNA methylation (24 CpG sites) 0.16 (0.005)  
 DNA methylation promoter region: TSS1500 and TSS200 (11 CpG sites) 0.20 (0.012)  
BMI (kg/m2)b
SLC22A1
 cg13434757 6 160541976 TSS1500 0.22 (0.045) 0.230
 cg13466809 6 160542944 1stExon;5′UTR 0.23 (<0.0001) <0.0001
 Average DNA methylation (13 CpG sites) 0.09 (0.013)  
 DNA methylation promoter region: TSS1500 and TSS200 (4 CpG sites) 0.16 (0.038)  
SLC22A3
 cg06295784 6 160771074 Body 0.28 (<0.0001) <0.0001
 cg09226986 6 160852328 Body − 0.12 (0.020) 0.153
 cg25313204 6 160768801 TSS1500 0.31 (<0.0001) <0.0001
 Average DNA methylation (23 CpG sites) 0.03 (0.261)  
 DNA methylation promoter region: TSS1500 and TSS200 (5 CpG sites) 0.06 (0.030)  
SLC47A1
 cg01530032 17 19435805 TSS1500 0.22 (0.029) 0.174
 cg10718608 17 19438221 Body 0.20 (0.003) 0.072
 cg12133118 17 19436770 TSS1500 0.17 (0.006) 0.072
 cg12550399 17 19482275 3′ UTR 0.26 (0.024) 0.174
 Average DNA methylation (24 CpG sites) 0.06 (0.001)  
 DNA methylation promoter region: TSS1500 and TSS200 (11 CpG sites) 0.06 (0.025)  
  1. q values are based on false discovery rate (FDR) tests
  2. B regression coefficient
  3. aAdjusted for age and sex
  4. bAdjusted for age, sex, and NASH