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Table 2 Differentially methylated cytosines (DMC; P < 0.05) post-surgery that were associated with SORBS3

From: Alterations of sorbin and SH3 domain containing 3 (SORBS3) in human skeletal muscle following Roux-en-Y gastric bypass surgery

  DNA methylation (%)   Total no. of reads      
Chr.8 position Pre-surgery Post-surgery P value Pre-surgery Post-surgery Strand Gene region CpG island region Correlated GE TFBM overlap
22,411,728 16.3 ± 5.8 7.0 ± 6.0 0.03 135.0 133.0 + 5′UTR South shelf   
22,411,729 6.6 ± 7.9 0.0 ± 0.0 0.005 89.0 106.0 5′UTR South shelf   
22,422,937 19.4 ± 25.1 5.8 ± 7.8 0.04 125.0 194.0 Promoter CpG island   AP-2alphaA
22,422,940 27.8 ± 24.8 10.2 ± 12.2 0.02 125.0 194.0 Promoter CpG island   
22,422,953 35.2 ± 22.2 11.2 ± 12.4 0.003 129.0 200.0 Promoter CpG island   Sp1
22,422,968 16.5 ± 10.6 5.3 ± 8.5 0.007 129.0 200.0 Promoter CpG island   
22,423,014 21.4 ± 14.6 7.7 ± 5.6 0.003 118.0 120.0 + Promoter CpG island   GCF
22,423,020 18.0 ± 7.8 7.5 ± 7.9 0.04 118.0 120.0 + Promoter CpG island   GCF
22,423,091 22.4 ± 11.2 7.9 ± 6.5 0.006 119.0 120.0 + Promoter CpG island   
22,423,100 17.2 ± 10.8 7.1 ± 5.7 0.03 119.0 120.0 + Promoter CpG island   CREB
22,423,111 10.7 ± 12.2 1.3 ± 2.1 0.02 119.0 120.0 + Promoter CpG island   
22,423,186 8.8 ± 12.5 22.4 ± 11.3 0.04 84.0 103.0 + 5′UTR CpG island   
22,423,198 13.8 ± 8.7 5.0 ± 3.9 0.03 130.0 158.0 + 5′UTR CpG island   
22,423,202 18.8 ± 13.2 8.8 ± 2.4 0.01 130.0 158.0 + 5′UTR CpG island   
22,423,204 7.9 ± 6.0 0.0 ± 0.0 0.0001 130.0 158.0 + 5′UTR CpG island   GCF
22,423,205 8.4 ± 5.4 1.9 ± 2.1 0.001 258.0 290.0 5′UTR CpG island   GCF
22,423,206 14.7 ± 7.7 6.9 ± 4.8 0.03 130.0 158.0 + 5′UTR CpG island   GCF
22,423,210 23.7 ± 11.2 14.1 ± 3.1 0.03 130.0 158.0 + 5′UTR CpG island   GCF
22,423,224 13.1 ± 8.5 3.3 ± 3.9 0.001 187.0 248.0 + 5′UTR CpG island   
22,423,235 17.4 ± 11.4 10.1 ± 3.0 0.04 228.0 289.0 + 5′UTR CpG island   Sp1/Pax5/p53
22,423,251 18.2 ± 12.1 8.4 ± 5.4 0.04 130.0 158.0 + 5′UTR CpG island   
22,423,519 28.0 ± 8.5 14.3 ± 5.8 0.002 193.0 216.0 + 5′UTR CpG island X  
22,423,529 29.8 ± 6.5 17.9 ± 8.1 0.005 184.0 207.0 + 5′UTR CpG island   
22,423,568 26.5 ± 9.0 16.0 ± 8.7 0.02 359.0 415.0 + 5′UTR CpG island   
22,423,689 46.8 ± 9.8 31.1 ± 13.6 0.01 252.0 310.0 + 5′UTR CpG island X GCF
22,423,690 50.6 ± 6.8 38.0 ± 16.5 0.04 276.0 342.0 5′UTR CpG island   GCF
22,423,702 38.4 ± 10.7 20.9 ± 14.5 0.007 278.0 345.0 5′UTR CpG island X  
22,423,736 18.5 ± 5.6 11.2 ± 4.4 0.007 363.0 441.0 + 5′UTR South shore   RXR-alpha
22,423,774 53.0 ± 14.2 32.1 ± 22.5 0.03 101.0 79.0 5′UTR South shore   
22,423,852 31.2 ± 11.9 15.0 ± 12.7 0.03 92.0 73.0 5′UTR South shore   
  1. DNA methylation data presented as mean ± SD
  2. GE correlated gene expression, TFBM transcription factor binding motif