Table 2 Differentially methylated cytosines (DMC; P < 0.05) post-surgery that were associated with SORBS3
DNA methylation (%) | Total no. of reads | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Chr.8 position | Pre-surgery | Post-surgery | P value | Pre-surgery | Post-surgery | Strand | Gene region | CpG island region | Correlated GE | TFBM overlap |
22,411,728 | 16.3 ± 5.8 | 7.0 ± 6.0 | 0.03 | 135.0 | 133.0 | + | 5′UTR | South shelf | ||
22,411,729 | 6.6 ± 7.9 | 0.0 ± 0.0 | 0.005 | 89.0 | 106.0 | − | 5′UTR | South shelf | ||
22,422,937 | 19.4 ± 25.1 | 5.8 ± 7.8 | 0.04 | 125.0 | 194.0 | − | Promoter | CpG island | AP-2alphaA | |
22,422,940 | 27.8 ± 24.8 | 10.2 ± 12.2 | 0.02 | 125.0 | 194.0 | − | Promoter | CpG island | ||
22,422,953 | 35.2 ± 22.2 | 11.2 ± 12.4 | 0.003 | 129.0 | 200.0 | − | Promoter | CpG island | Sp1 | |
22,422,968 | 16.5 ± 10.6 | 5.3 ± 8.5 | 0.007 | 129.0 | 200.0 | − | Promoter | CpG island | ||
22,423,014 | 21.4 ± 14.6 | 7.7 ± 5.6 | 0.003 | 118.0 | 120.0 | + | Promoter | CpG island | GCF | |
22,423,020 | 18.0 ± 7.8 | 7.5 ± 7.9 | 0.04 | 118.0 | 120.0 | + | Promoter | CpG island | GCF | |
22,423,091 | 22.4 ± 11.2 | 7.9 ± 6.5 | 0.006 | 119.0 | 120.0 | + | Promoter | CpG island | ||
22,423,100 | 17.2 ± 10.8 | 7.1 ± 5.7 | 0.03 | 119.0 | 120.0 | + | Promoter | CpG island | CREB | |
22,423,111 | 10.7 ± 12.2 | 1.3 ± 2.1 | 0.02 | 119.0 | 120.0 | + | Promoter | CpG island | ||
22,423,186 | 8.8 ± 12.5 | 22.4 ± 11.3 | 0.04 | 84.0 | 103.0 | + | 5′UTR | CpG island | ||
22,423,198 | 13.8 ± 8.7 | 5.0 ± 3.9 | 0.03 | 130.0 | 158.0 | + | 5′UTR | CpG island | ||
22,423,202 | 18.8 ± 13.2 | 8.8 ± 2.4 | 0.01 | 130.0 | 158.0 | + | 5′UTR | CpG island | ||
22,423,204 | 7.9 ± 6.0 | 0.0 ± 0.0 | 0.0001 | 130.0 | 158.0 | + | 5′UTR | CpG island | GCF | |
22,423,205 | 8.4 ± 5.4 | 1.9 ± 2.1 | 0.001 | 258.0 | 290.0 | − | 5′UTR | CpG island | GCF | |
22,423,206 | 14.7 ± 7.7 | 6.9 ± 4.8 | 0.03 | 130.0 | 158.0 | + | 5′UTR | CpG island | GCF | |
22,423,210 | 23.7 ± 11.2 | 14.1 ± 3.1 | 0.03 | 130.0 | 158.0 | + | 5′UTR | CpG island | GCF | |
22,423,224 | 13.1 ± 8.5 | 3.3 ± 3.9 | 0.001 | 187.0 | 248.0 | + | 5′UTR | CpG island | ||
22,423,235 | 17.4 ± 11.4 | 10.1 ± 3.0 | 0.04 | 228.0 | 289.0 | + | 5′UTR | CpG island | Sp1/Pax5/p53 | |
22,423,251 | 18.2 ± 12.1 | 8.4 ± 5.4 | 0.04 | 130.0 | 158.0 | + | 5′UTR | CpG island | ||
22,423,519 | 28.0 ± 8.5 | 14.3 ± 5.8 | 0.002 | 193.0 | 216.0 | + | 5′UTR | CpG island | X | |
22,423,529 | 29.8 ± 6.5 | 17.9 ± 8.1 | 0.005 | 184.0 | 207.0 | + | 5′UTR | CpG island | ||
22,423,568 | 26.5 ± 9.0 | 16.0 ± 8.7 | 0.02 | 359.0 | 415.0 | + | 5′UTR | CpG island | ||
22,423,689 | 46.8 ± 9.8 | 31.1 ± 13.6 | 0.01 | 252.0 | 310.0 | + | 5′UTR | CpG island | X | GCF |
22,423,690 | 50.6 ± 6.8 | 38.0 ± 16.5 | 0.04 | 276.0 | 342.0 | − | 5′UTR | CpG island | GCF | |
22,423,702 | 38.4 ± 10.7 | 20.9 ± 14.5 | 0.007 | 278.0 | 345.0 | − | 5′UTR | CpG island | X | |
22,423,736 | 18.5 ± 5.6 | 11.2 ± 4.4 | 0.007 | 363.0 | 441.0 | + | 5′UTR | South shore | RXR-alpha | |
22,423,774 | 53.0 ± 14.2 | 32.1 ± 22.5 | 0.03 | 101.0 | 79.0 | − | 5′UTR | South shore | ||
22,423,852 | 31.2 ± 11.9 | 15.0 ± 12.7 | 0.03 | 92.0 | 73.0 | − | 5′UTR | South shore | ||