Fig. 5
From: Epigenetic response of imprinted domains during carcinogenesis
DNA methylation trends during carcinogenesis. a The genome-wide reductions in 5-methylcytosine during the transition of normal cells to benign tumor cells (first hash mark) and when benign cells gain infiltrative potential (second hash mark). b Specific hypermethylation events that coincide with the genome-wide hypomethylation trends. The red line represents hypermethylation at tumor suppressor gene (TSG) promoters and the blue line represents hypermethylation at imprinting control regions (ICRs)