Fig. 2
From: Epigenetic response of imprinted domains during carcinogenesis
DNA methylation signatures at ICRs in benign squamous papilloma and infiltrative thymic T cell lymphoma. a Mean percent methylation with 95% confidence intervals from 11 ICRs in squamous papilloma generated by COBRA. Data from 7 out of the 15 squamous papilloma tumors are shown and compared to a normal sample denoted with an N. b Mean percent methylation with 95% confidence intervals from 11 ICRs in thymic lymphoma generated by COBRA. Data from 3 representative thymic lymphoma samples (A—hyperplastic, B—atypical hyperplastic, and C—neoplastic) are compared to normal thymus tissues labeled N. c Summary of DNA methylation changes at the 11 ICRs in papilloma and thymoma. Red represents significant hypermethylation based on the samples having a P value less than 0.05, and gray represents no significant DNA methylation changes detected