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Table 3 Prognostic impact of miR-124 methylation levels and haematological factors in patients with MDS

From: Pyrosequencing quantified methylation level of miR-124 predicts shorter survival for patients with myelodysplastic syndrome

Variables

Overall survival (OS)

Leukaemia-free survival (LFS)

No. of

No. of

Univariate

Multivariate

No. of

Univariate

Multivariate

patients

event

P

P

event

P

P

Sex

  

0.326

 

0.513

 Male

36

20

  

9

  

 Female

20

14

  

6

  

Age

  

0.103

 

0.023

0.002

  < 60

25

12

  

3

  

  ≥ 60

31

22

  

12

  

WBC (× 109/L)

  

0.932

 

0.313

  ≥ 4

13

8

  

2

  

  < 4

43

26

  

13

  

Hb(g/dL)

  

0.058

 

0.050

  ≥ 10

9

4

  

0

  

  < 10

47

30

  

15

  

PLT (× 109/L)

  

0.469

 

0.702

  ≥ 100

18

9

  

4

  

  < 100

38

25

  

11

  

MCV(fL)

  

0.014

0.111

 

0.861

  ≥ 100

28

13

  

8

  

  < 100

28

21

  

7

  

WHO classification

  

<0.001

0.016

 

0.003

0.944

 SLD/RS-SLD/

MDS-U/5q-

10

5

  

0

  

 MLD/RS-MLD

10

2

  

0

  

 EB-1/EB-2

36

27

  

15

  

BM blast (%)

  

<0.001

0.003

 

<0.001

0.453

  < 5

20

7

  

0

  

 5–10

15

10

  

3

  

 11–19

21

17

  

12

  

Cytopenias

  

0.391

 

0.19

 0/1

11

5

  

1

  

 2/3

45

29

  

14

  

Karyotype

  

0.005

<0.001

 

0.626

 Good

34

18

  

9

  

 Intermediate

7

5

  

2

  

 Poor

14

11

  

4

  

IPSS

  

0.002

0.007

 

0.004

0.122

 Low

4

1

  

0

  

 Int-1

24

12

  

2

  

 Int-2

19

14

  

10

  

 High

8

7

  

3

  

miR-124-1 methylation

  

0.025

0.810

 

0.029

0.125

 Low

33a,43b

17

  

9

  

 High

23 a,13b

17

  

6

  

miR-124-2 methylation

  

0.004

0.312

 

0.001

0.307

 Low

27

13

  

2

  

 High

29

21

  

13

  

miR-124-3 methylation

  

0.010

0.028

 

0.069

-

 Low

21

10

  

3

  

 High

35

24

  

12

  
  1. Different cut-off values of methylation levels were used to predict OS and LFS (Tables 1 and 2); therefore, ameans the number of patients with low or high methylation levels to predict OS, and bmeans the number of patients with low or high methylation levels to predict LFS
  2. Italics are statistically significant