The impact of methylation quantitative trait loci (mQTLs) on active smoking-related DNA methylation changes

Clinical Epigenetics

Table 5 Impact of rs75509302-smoking interaction on the methylation level of cg23576855^a

Gene	CpG site	SNP	SNP-smoking interaction^b				Smoking status^d
			Genotype^c	Coefficient	SE	p value	Coefficient	SE	p value
AHRR	cg23576855	rs75509302	TT	Ref			−0.182	7.1 e − 3	3.8 e − 95
			CT	0.128	0.013	1.1 e − 20
			CC	0.268	0.033	2.5 e − 15

^aModel is fully adjusted for age, sex, BMI, smoking status (current and never smoking only), alcohol consumption, physical activity, prevalence of CVD, diabetes and cancer at baseline. The methylation levels of CpG sites were responses, the SNPs and SNP-smoking interactions were predictors;
^bThe never smoking * genotype groups and current smoking * TT group were used as references;
^cThe group of interaction between current smoking and listed genotype;
^dNever smoking was used as reference

ISSN: 1868-7083