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Table 4 Three most frequently identified mQTLs and corresponding CpG sites

From: The impact of methylation quantitative trait loci (mQTLs) on active smoking-related DNA methylation changes

SNP

Chr

SNP positiona

Minor allele

MAFb

CpG

Distance (bp)c

FDRd

rs75509302

5

365,653

C

0.144

cg23576855

− 7647

3.4 e − 100

     

cg11902777

− 3190

1.4 e − 7

     

cg17287155

− 27,694

7.8 e − 5

     

cg03991871

− 2795

1.0 e − 4

     

cg12806681

− 2742

1.2 e − 4

     

cg23916896

− 3152

9.5 e − 4

     

cg03604011

− 34,548

1.1 e − 3

     

cg14817490

− 27,267

2.1 e − 3

rs34835481

1

92,991,624

T

0.210

cg10399789

45,956

2.2 e − 5

     

cg12876356

44,799

1.3 e − 3

     

cg09662411

45,492

1.9 e − 3

     

cg18146737

44,923

2.0 e − 3

     

cg18316974

44,589

3.0 e − 3

     

cg09935388

44,036

0.016

rs79050605

1

92,925,962

G

0.202

cg12876356

− 20,863

3.7 e − 4

     

cg18146737

− 20,739

1.1 e − 3

     

cg18316974

− 21,073

1.7 e − 3

     

cg09662411

− 20,170

1.9 e − 3

     

cg09935388

− 21,626

2.2 e − 3

  1. aSNPs positions were based on GRCh37/hg19
  2. bMAF minor allele frequency
  3. cThe distance between SNP and CpG (SNP position–CpG position)
  4. dThe FDR-corrected p values of SNPs in fully adjusted mixed linear regression models, which controlled for age (years), sex, smoking status, random batch effect of methylation measurement, leukocyte distribution (Houseman algorithm), alcohol consumption (abstainer/low/intermediate/high), body mass index (BMI, underweight or normal weight/overweight/obese), physical activity (inactive/low/medium or high), prevalence of cardiovascular diseases (yes/no), prevalence of diabetes (yes/no), and prevalence of cancer (yes/no)
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Clinical Epigenetics

ISSN: 1868-7083

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