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Table 3 The best and worst AUC values among the 18 genes evaluated in this study. KIF1A showed a minimal variation among all 27 CpGs interrogated, whereas TERT displayed the widest gap between different AUC, highlighting the importance of CpG location

From: CpG location and methylation level are crucial factors for the early detection of oral squamous cell carcinoma in brushing samples using bisulfite sequencing of a 13-gene panel

Gene Best AUC position Best AUC value Worst AUC position Worst AUC value Best to worst AUC gap
KIF1A Chr2: 241759621 0.94 Chr2: 241759702 0.87 0.0694444
MIR137 Chr1: 98046097 0.78 Chr1: 98046237 0.69 0.0916666
GP1BB Chr22: 19710956 0.97 Chr22: 19710954 0.88 0.0921717
H19 Chr11: 2018169 0.66 Chr11: 2018228 0.56 0.0992425
LRRTM1 Chr2: 80531799 0.9 Chr2: 80531776 0.8 0.1012626
NTM Chr11: 131781167 0.86 Chr11: 131781080 0.75 0.1063131
ZAP70 Chr2: 98340854 0.96 Chr2: 98340816 0.85 0.1073232
MIR193A Chr17: 29886944 0.84 Chr17: 29886881 0.72 0.1252525
EPHX3 Chr19: 15342885 0.83 Chr19: 15342831 0.71 0.1260101
LINC00599 Chr8: 9760888 0.83 Chr8: 9760805 0.69 0.1436869
FLI1 Chr11: 128564158 0.84 Chr11: 128564065 0.67 0.1643940
PAX1 Chr20: 21686312 0.9 Chr20: 21686253 0.74 0.1648990
ITGA4 Chr2: 1823229.02 0.84 Chr2: 182323028 0.66 0.1813131
PARP15 Chr3: 122296586 0.84 Chr3: 122296671 0.65 0.1919191
TERT Chr5: 1279758 0.92 Chr5: 1279838 0.67 0.2563132
MIR296 Chr20: 57392374 0.75 Chr20: 57392419 0.44 0.3151516
DNMT1 Chr19: 10305597 0.67 Chr19: 10305652 0.34 0.3338384
TERC Chr3: 169482446 0.69 Chr3: 169482370 0.28 0.4047980