Fig. 2
From: Epigenetic regulation of inflammation in localized aggressive periodontitis
DNA methylation levels of anti-inflammatory genes in periodontitis vs control subjects. ANOVA with Tukey’s comparisons or Kruskal-Wallis with Dunn’s comparisons were carried out among healthy controls (HC), localized aggressive moderate (Mod), and severe (Sev) periodontitis. ***p < 0.001, **p < 0.01, *p < 0.05. Note that severe aggressive periodontitis displays lower methylation levels in several genes when compared to moderate periodontitis, while moderate disease shows higher methylation levels in general. TLR-2 signaling genes that are anti-inflammatory: FADD Fas-associated protein with death domain(c), IRAKBP1 interleukin 1 receptor-associated kinase 1 binding protein 1(a), PPARA peroxisome proliferator-activated receptor alpha(b)