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Table 2 Chidamide enhanced the cytotoxicity of IDA, DNR, or Ara-C to CD34+CD38 KG1α and Kasumi cells in vitro

From: Cooperative effect of chidamide and chemotherapeutic drugs induce apoptosis by DNA damage accumulation and repair defects in acute myeloid leukemia stem and progenitor cells

Drug IC50 (nM) of KG1α Fold P IC50 (nM) of Kasumi Fold P
Single Combination Single Combination
IDA         
 24 h 92.36 ± 7.26 75.65 ± 14.36 1.22 0.146 85.67 ± 11.61 53.86 ± 10.75 1.59 0.025
 48 h 56.96 ± 5.64 39.17 ± 6.50 1.45 0.023 26.13 ± 2.53 15.63 ± 1.21 1.84 0.003
 72 h 40.99 ± 15.57 17.23 ± 5.88 2.38 0.024 17.23 ± 1.54 11.33 ± 0.95 1.52 0.005
DNR         
 24 h 500 ± 17.58 468.56 ± 21.35 1.07 0.209 324.81 ± 34.75 171.71 ± 32.41 1.89 0.005
 48 h 257.90 ± 9.66 205.82 ± 7.23 1.25 0.002 160.97 ± 21.54 67.95 ± 8.09 2.37 0.002
 72 h 224.20 ± 5.80 95.78 ± 5.91 2.34 <0.001 80.52 ± 13.36 47.20 ± 5.57 1.71 0.016
Ara-C         
 24 h >106 >106 7920.75 ± 5131.77 3842.19 ± 2732.90 2.06 0.291
 48 h 435.82 ± 51.23 313.13 ± 48.44 1.39 0.039 476.32 ± 29.21 300.70 ± 34.38 1.58 0.003
 72 h 334.27 ± 28.76 127.84 ± 11.21 2.61 <0.001 181.46 ± 10.77 115.85 ± 6.83 1.54 0.001
  1. Note: CD34+CD38 KG1α and Kasumi cells were exposed to IDA, DNR, or Ara-C with or without chidamide (0.75 μM) for 24, 48, and 72 h, with cytotoxicity being assessed using a CCK-8 assay