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Table 2 DNA methylation in specific CpG sites

From: High levels of circulating folate concentrations are associated with DNA methylation of tumor suppressor and repair genes p16, MLH1, and MGMT in elderly Chileans

Genes CpG site Men (n = 77) Women (n = 172) Total (n = 249)
LINE-1 1 86.2 (84.5–86.9) 85.75 (84.5–86.9) 85.8 (84.8–86.7)
2 82.6 (82.3–82.8) 82.5 (82.2–82.8) 82.5 (82.3–82.7)
3 80.875 (80.4–81.75) 80.9 (80.3–81.3) 80.9 (80.5–81.2)
4 82.2 (81.3–83.2) 82.0 (81.6–82.4) 82.0 (81.7–82.4)
Average 83.3 (82.8–83.8) 82.8 (82.6–83.3) 82.9 (82.65–83.4)
p16 1 3.36 (3.0–3.89) 3.46 (3.25–3.64) 3.44 (3.25–3.6)
2 1.575 (1.16–1.9) 1.58 (1.45–1.87) 1.58 (1.46–1.79)
3 1.88 (1.37–2.12) 1.84 (1.62–2.07) 1.85 (1.66–2.04)
4* 2.2 (1.91–2.25) 1.88 (1.75–2.05) 1.96 (1.82–2.11)
5 0.91 (0–1.60) 1.65 (1.41–1.92) 1.49 (1.34–1.77)
6 0 0 0
7 1.89 (1.38–2.23) 1.94 (1.73–2.12) 1.91 (1.71–2.09)
Average 1.89 (1.66–2.06) 1.92 (1.78–2.02) 1.907 (1.79–2.01)
MLH1 1 0 (0–0.99) 0 0
2 1.39 (0–2.35) 1.82 (0–2.10) 1.725 (0–2.07)
3 0 0 0
4γ 2.3 (1.75–2.80) 2.495 (1.96–2.84) 2.435 (1.97–2.77)
Average 1.25 (0.70–1.38) 1.12 (0.74–1.31) 1.165 (0.81–1.31)
MGMT 1 3.345 (2.53–4.21) 4.01 (3.51–4.66) 3.8 (3.41–4.26)
2 0 (0–1.65) 0 (0–1.88) 0
3 0 0 0
4 1.865 (1.38–2.31) 1.87 (1.61–2.26) 1.87 (1.61–2.15)
5 0 0 0
6 0 0 0
Average 1.555 (1.10–2.11) 1.72 (1.39–1.87) 1.66 (1.44–1.87)
  1. Results are expressed as percentages of methylation and 95% CI. Two-sample Wilcoxon rank-sum test *p = 0.04; γ p = 0.07; for other results p > 0.1