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Table 2 Active children with high exposure to BC have lower FOXP3 promoter methylation compared to non-active children with high BC

From: Physical activity, black carbon exposure, and DNA methylation in the FOXP3 promoter

  Difference in percent methylation in active vs. non-active children
β estimate (95% confidence interval)
Overall sample
(n = 135)
High BCa
(n = 63)
Low BCa
(n = 72)
p interaction
Promoter 1 −0.59 (−1.72, 0.54) −1.32 (−2.74, 0.11) 0.30 (−1.36, 1.97) NA
Promoter 2 −0.60 (−1.79, 0.60) −2.37 (−4.04, −0.70) 0.54 (−1.12, 2.20) 0.04
Promoter 3 −0.68 (−2.10, 0.74) −2.57 (−4.62, −0.51) −0.41 (−2.16, 1.34) 0.26
  1. β estimate represents the effect size or the difference in percent methylation when comparing active children to non-active children (reference). Models adjusted for age, sex, race/ethnicity, BMI Z-score, asthma, atopy, secondhand smoke exposure, BC (only in non-stratified model), and heating season. Italicized values represent p value ≤0.01 and p < 0.05 for interaction term. P interaction represents the p value for the interaction term between physical activity and BC
  2. aDichotomized at the median, 1210 ng/m3