From: Prognostic significance of LINE-1 hypomethylation in oropharyngeal squamous cell carcinoma
Variables | Cases, n = 28 | Controls, n = 49 | OR (95% CI)a | OR (95% CI)b | ||
---|---|---|---|---|---|---|
n | (%) | n | (%) | |||
Gender | ||||||
Male | 19 | (67.9) | 33 | (67.4) | 1f | 1f |
Female | 9 | (32.1) | 16 | (32.7) | 1.07 (0.38–2.97) | 1.08 (0.37–3.18) |
Age (years) | ||||||
<55 | 10 | (35.7) | 18 | (36.7) | 1f | 1f |
55–59 | 10 | (35.7) | 12 | (24.5) | 1.52 (0.47–4.91) | 1.66 (0.49–5.66) |
≥60 | 8 | (28.6) | 19 | (38.8) | 0.76 (0.25–2.37) | 0.90 (0.27–3.00) |
Smoking habits | ||||||
Never | 4 | (14.3) | 10 | (20.4) | 1f | 1f |
Former | 3 | (10.7) | 11 | (22.5) | 0.62 (0.11–3.62) | 0.66 (0.11–4.12) |
Current | 21 | (75.0) | 28 | (57.1) | 1.73 (0.46–6.54) | 1.44 (0.32–6.45) |
Nc, d | ||||||
0–1 | 5 | (17.9) | 15 | (31.3) | 1f | 1f |
2–3 | 23 | (82.1) | 33 | (68.7) | 2.02 (0.63–6.55) | 1.12 (0.42–2.99) |
Tc, d | ||||||
1–2 | 11 | (39.3) | 31 | (64.6) | 1f | 1f |
3–4 | 17 | (60.7) | 17 | (35.4) | 3.23 (1.18–8.86) | 1.92 (1.02–3.62) |
Stage | ||||||
III | 4 | (13.8) | 12 | (25.0) | 1f | 1f |
IV | 25 | (86.2) | 36 | (75.0) | 2.77 (0.68–11.30) | 2.44 (0.58–10.29) |
HPV16 | ||||||
Negative | 23 | (82.1) | 36 | (73.5) | 1f | 1e |
Positive | 5 | (17.9) | 13 | (26.5) | 0.59 (0.18–1.93) | 0.92 (0.24–3.61) |
Therapyc | ||||||
RT ± CT | 16 | (57.1) | 21 | (42.9) | 1f | 1f |
RT + CH ± CT | 12 | (42.9) | 28 | (57.1) | 0.53 (0.20–1.45) | 0.48 (0.16–1.51) |
LINE-1 methylation | ||||||
≥70% | 6 | (21.4) | 19 | (38.8) | 1f | 1f |
50 to <70% | 9 | (32.1) | 17 | (34.7) | 1.68 (0.48–5.83) | 2.18 (0.53–8.97) |
<50% | 13 | (46.4) | 13 | (26.5) | 3.51 (1.03–12.00) | 4.12 (1.01–16.91) |
Continuous 10% decreasee | 1.45 (1.13–1.87) | 1.50 (1.13–2.00) |