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Table 1 Clinicopathological features of 41 patients diagnosed with papillary thyroid carcinoma

From: Integrated data analysis reveals potential drivers and pathways disrupted by DNA methylation in papillary thyroid carcinomas

Characteristics Number Frequency (%)
Age (years)
 Median (interquartile range) 39(20-77)  
 <55 34 83
 ≥55 7 17
Gender
 Female 30 73
 Male 11 27
Size Tumor (cm)
 Median (range) 1.2(0.6-3.2)  
mPTC (≤1) 18 44
 PTC (>1) 23 56
Predominant variant   
 Classic 29 71
 Follicular 7 17
 Othera 3 7
 Not available 2 5
Multicentricity
 No 17 41
 Yes 24 59
Extrathyroidal extension
 No 20 49
 Yes 21 51
Lymph Nodes involvement
 No 25 61
 Yes 16 39
Angiolymphatic invasion
 No 39 95
 Yes 1 5
Perineural invasion   
 No 36 88
 Yes 2 5
 Not available 3 7
Outcome
 Favorableb 36 88
 Poor c 5 12
Follow-up
 >5 years 36 88
 <5 years 5 12
Somatic alterations
 BRAF mutation 28 68
 BRAF wild-type 13 32
 RAS mutation 0 0
 RAS wild-type 41 100
 RET/PTC inversion 5 12
 RET/PTC wild-type 36 88
  1. mPTC Papillary thyroid microcarcinoma
  2. aThree rare variants were grouped: one tall cells, one oncocytic, and one mucosecretory
  3. bPatients without any suspicion of active disease by imaging scan and/or serum thyroglobulin measurement in at least 5 years of follow-up
  4. cPatients with confirmed recurrent disease in the follow-up