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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Integrated data analysis reveals potential drivers and pathways disrupted by DNA methylation in papillary thyroid carcinomas

Fig. 2

Classification of the differentially methylated probes in PTC. a Supervised hierarchical clustering analysis showed 6070 differentially methylated probes in papillary thyroid carcinoma (PTC) versus normal thyroid (NT) tissues, mostly hypomethylated in PTC. The first cluster shows all normal samples (purple) and six PTC (orange), and the second is composed exclusively by tumor samples (orange). The beta values vary between zero (green) and one (red). b Methylation probes identified in PTC versus NT and those detected in the integrative analysis with negative (r−) and positive correlation (r+) according to the functional genomic distribution, CpG content, and neighborhood context and enhancer representation

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Clinical Epigenetics

ISSN: 1868-7083

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