Table 3 CV health-related overrepresented pathways identified from differential methylation analysis following an n-3 FA supplementation

Tumoricidal function of hepatic natural killer cells^a

0.0017

BAX, CASP6, FAS

RAR activation^a

0.0035

AKT3, DHRS9, PRKAG2, PRKCZ, PRKD3, PTEN, TRIM24

VDR/RXR activation^b

0.0078

IGFBP5, KLK6, PRKCZ, PRKD3

Fcγ receptor-mediated phagocytosis in macrophages and monocytes^a

0.017

AKT3, PRKCZ, PRKD3, PTEN

D-myo-inositol-5-phosphate metabolism^b

0.018

NUDT3, PLCH1, PPP2R5E, PTEN, PTPN12

Nitric oxide signaling in the cardiovascular system^c

0.026

AKT3, PRKAG2, PRKCZ, PRKD3

IL-3 signaling^a

0.033

AKT3, PRKCZ, PRKD3

PXR/RXR activation^b

0.035

AKT3, SLCO1B3, PRKAG2

LPS-stimulated MAPK signaling^a

0.035

ATF1, PRKCZ, PRKD3

NF-кB activation by viruses^a

0.037

AKT3, PRKCZ, PRKD3

CCR5 signaling in nacrophages^a

0.037

FAS, PRKCZ, PRKD3

Role of NFAT in cardiac hypertrophy^c

0.038

AKT3, HDAC4, PRKAG2, PRKCZ, PRKD3

P2Y purigenic receptor signaling pathway^c

0.040

AKT3, PRKAG2, PRKCZ, PRKD3

Cytotoxic T lymphocyte-mediated apoptosis of target cells^a

0.040

FAS, CASP6

PI3K signaling in B lymphocytes^a

0.044

AKT3, ATF1, PRKCZ, PTEN

Type II diabetes mellitus signaling^d

0.049

AKT3, PRKAG2, PRKCZ, PRKD3