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Table 3 Significant differential methylation within genes involved in mesothelial lineage and development

From: Genome-wide DNA methylation analysis reveals loci that distinguish different types of adipose tissue in obese individuals

     Before weight loss After weight loss
Differential analysis
Illumina probe ID CpG site chromosome and positiona UCSC gene name Location AB mean beta OM mean beta Δbeta Adjusted P value AB mean beta OM mean beta Δbeta Adjusted P value
cg01168289 11:32421514 WT1 Body      0.584 0.745 −0.161 0.030
cg27019929 11:3421518 WT1 Body      0.626 0.845 −0.221 2.1 × 10−4
cg24325551 11:3421635 WT1 Body 0.502 0.713 −0.211 0.002 0.425 0.665 −0.241 2.1 × 10−5
cg20449659 11:3421752 WT1 Body 0.594 0.795 −0.201 0.03 0.469 0.751 −0.282 5.7 × 10−6
cg08575722 11:3421845 WT1 Body      0.36 0.622 −0.262 0.003
cg09695430 11:32447944 WT1 Body 0.326 0.527 −0.2 1.2 × 10−4 0.259 0.557 −0.298 1.2 × 10−5
cg20204986 11:32448067 WT1 Body 0.406 0.596 −0.19 0.001 0.314 0.596 −0.281 2.1 × 10−4
cg13638420 11:32448293 WT1 Body 0.236 0.391 −0.155 0.014 0.195 0.447 −0.253 0.009
cg12006284 11:32449638 WT1 Body 0.303 0.448 −0.145 0.022     
cg13540960 11:32450244 WT1 Body 0.082 0.270 −0.188 0.05     
cg05222924 11:32450486 WT1 Body 0.072 0.238 −0.166 1.3 × 10−4     
cg19211915 11:32452513 WT1 Body 0.183 0.250 −0.067 0.03     
cg09234616 11:32452592 WT1 Body 0.074 0.203 −0.129 0.025     
cg08079266 16:817098 MSLN Body 0.877 0.922 −0.045 0.03     
cg04476874 19:345778 MIER2 TSS1500      0.527 0.735 −0.208 2.7 × 10−5
Biomarker approach
Illumina probe ID CpG site chromosome and positiona UCSC gene name Location AB mean beta OM mean beta Δbeta Merit score AB mean beta OM mean beta Δbeta Merit score
cg05069835 7:76139338 UPK3B TSS1500      0.49 0.557 −0.067 0.006
cg24325551 11:3421635 WT1 Body 0.502 0.713 −0.211 0.109     
cg10244666 11:3421808 WT1 Body      0.639 0.357 0.282 0.130
cg08575722 11:3421845 WT1 Body 0.479 0.648 −0.169 0.035     
cg20204986 11:32448067 WT1 Body 0.406 0.596 −0.19 0.086     
cg13638420 11:32448293 WT1 Body      0.447 0.195 0.252 0.147
cg12006284 11:32449638 WT1 Body      0.506 0.274 0.232 0.074
cg04456238 11:32450104 WT1   0.301 0.437 −0.136 0.025 0.481 0.251 0.23 0.069
cg13540960 11:32450244 WT1   0.082 0.27 −0.188 0.099     
cg05222924 11:32450486 WT1       0.316 0.091 0.225 0.099
cg06516124 11:32450591 WT1   0.089 0.184 −0.095 0.017     
cg09234616 11:32452592 WT1   0.074 0.203 −0.129 0.049     
cg15315385 11:32452839 WT1       0.27 0.169 0.101 0.016
cg04130356 16:810643 MSLN TSS1500      0.686 0.789 −0.103 0.04
cp0838005 16:816149 MSLN Body      0.946 0.883 0.063 0.006
cg08581018 16:832942 MSLNL TSS200      0.621 0.722 −0.101 0.015
cg16804923 16:834399 MSLNL TSS1500 0.838 0.898 −0.06 0.012 0.861 0.756 0.105 0.029
cg04476874 19:345778 MIER2 TSS1500      0.735 0.527 0.208 0.134
  1. Illumina probe IDs in bold indicate probes which overlap between the two analytical approaches
  2. aGene symbol and map position as Illumina manifest, GRCh37/hg19