Fig. 6

Methylation of the robust discriminatory probes from each analysis in publically available adipose tissue data. Box plots of the methylation beta values (Illumina 450K analysis) for cg00838040 and the top 10 probes from the before weight loss analysis. Subcutaneous adipose is prefaced AB in all cases and omental or visceral adipose OM. Data from the current study is shaded grey with before weight loss samples indicated by ‘pre’ (i.e. AB_pre and OM_pre) and after weight loss shown as AB_post and OM_post. Publically available data is as follows: AB_Glut and AB_SC indicate paired gluteal and abdominal subcutaneous samples, respectively, from normal weight females (GSE47513 [35]); AB_PM and OM_PM indicate data from six paired subcutaneous adipose and omentum samples, respectively, taken 12 h post-mortem from normal-weight males (GSE48472 [43]); AB_twin indicates subcutaneous abdominal adipose data from 642 individuals from the MuTHER twin study [46, 47] (EBI E-MTAB-1866) who had an average BMI of 26.7 (±4.9) [45]