Table 2 Associations between adiposity and LEP and ADIPOQ SAT DNA methylation and expression after 36 h fasting
LBW | NBW | Groups combined | LBW | NBW | Groups combined | LBW | NBW | Groups combined | |
|---|---|---|---|---|---|---|---|---|---|
LEP | Mean LEP DNA methylation assay 1 | Mean LEP DNA methylation assay 2 | P-leptin (μg/L) | ||||||
Gene expression | 0.23 (0.33) | 0.13 (0.62) | 0.23 (0.17) | 0.08 (0.75) | 0.63 (0.01) | 0.27 (0.10) | 0.30 (0.20) | 0.78 (<0.001) | 0.47 (0.004) |
BMI (kg/m2) | 0.35 (0.13) | 0.06 (0.82) | 0.22 (0.19) | 0.19 (0.41) | 0.22 (0.40) | 0.21 (0.21) | 0.47 (0.03) | 0.68 (0.002) | 0.52 (<0.001) |
Total BF% | 0.45 (0.05) | 0.18 (0.49) | 0.35 (0.03) | 0.45 (0.04) | 0.39 (0.12) | 0.42 (0.009) | 0.42 (0.06) | 0.83 (<0.001) | 0.61 (<0.001) |
P-leptin (μg/L) | 0.60 (0.006) | 0.16 (0.53) | 0.49 (0.002) | 0.04 (0.76) | 0.27 (0.29) | 0.18 (0.28) | – | – | – |
ADIPOQ | Mean ADIPOQ DNA methylation assay 1 | Mean ADIPOQ DNA methylation assay 2 | P-adiponectin (mg/L) | ||||||
Gene expression | 0.15 (0.52) | −0.23 (0.38) | −0.02 (0.89) | −0.30 (0.19) | −0.24 (0.37) | −0.31 (0.07) | 0.07 (0.78) | 0.15 (0.57) | 0.001 (0.99) |
BMI (kg/m2) | 0.12 (0.62) | 0.14 (0.58) | 0.14 (0.39) | 0.12 (0.60) | 0.04 (0.87) | 0.08 (0.64) | −0.21 (0.35) | −0.65 (0.003) | −0.44 (0.005) |
Total BF% | 0.23 (0.33) | 0.69 (0.002) | 0.44 (0.007) | 0.35 (0.13) | 0.21 (0.42) | 0.28 (0.10) | −0.17 (0.46) | −0.34 (0.17) | −0.17 (0.30) |
P-adiponectin (mg/L) | −0.47 (0.04) | −0.17 (0.51) | −0.32 (0.05) | −0.10 (0.69) | −0.17 (0.52) | −0.13 (0.44) | – | – | – |