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Table 2 Associations between adiposity and LEP and ADIPOQ SAT DNA methylation and expression after 36 h fasting

From: 36 h fasting of young men influences adipose tissue DNA methylation of LEP and ADIPOQ in a birth weight-dependent manner

  LBW NBW Groups combined LBW NBW Groups combined LBW NBW Groups combined
LEP Mean LEP DNA methylation assay 1 Mean LEP DNA methylation assay 2 P-leptin (μg/L)
 Gene expression 0.23 (0.33) 0.13 (0.62) 0.23 (0.17) 0.08 (0.75) 0.63 (0.01) 0.27 (0.10) 0.30 (0.20) 0.78 (<0.001) 0.47 (0.004)
 BMI (kg/m2) 0.35 (0.13) 0.06 (0.82) 0.22 (0.19) 0.19 (0.41) 0.22 (0.40) 0.21 (0.21) 0.47 (0.03) 0.68 (0.002) 0.52 (<0.001)
 Total BF% 0.45 (0.05) 0.18 (0.49) 0.35 (0.03) 0.45 (0.04) 0.39 (0.12) 0.42 (0.009) 0.42 (0.06) 0.83 (<0.001) 0.61 (<0.001)
 P-leptin (μg/L) 0.60 (0.006) 0.16 (0.53) 0.49 (0.002) 0.04 (0.76) 0.27 (0.29) 0.18 (0.28)
ADIPOQ Mean ADIPOQ DNA methylation assay 1 Mean ADIPOQ DNA methylation assay 2 P-adiponectin (mg/L)
 Gene expression 0.15 (0.52) −0.23 (0.38) −0.02 (0.89) −0.30 (0.19) −0.24 (0.37) −0.31 (0.07) 0.07 (0.78) 0.15 (0.57) 0.001 (0.99)
 BMI (kg/m2) 0.12 (0.62) 0.14 (0.58) 0.14 (0.39) 0.12 (0.60) 0.04 (0.87) 0.08 (0.64) −0.21 (0.35) −0.65 (0.003) −0.44 (0.005)
 Total BF% 0.23 (0.33) 0.69 (0.002) 0.44 (0.007) 0.35 (0.13) 0.21 (0.42) 0.28 (0.10) −0.17 (0.46) −0.34 (0.17) −0.17 (0.30)
 P-adiponectin (mg/L) −0.47 (0.04) −0.17 (0.51) −0.32 (0.05) −0.10 (0.69) −0.17 (0.52) −0.13 (0.44)
  1. Data are given as R coefficient (p value). p values <0.07 are bold. N = 20 LBW and 17 NBW for all data, except for gene expression data: N = 20 LBW and 16 NBW
  2. SAT subcutaneous adipose tissue, LBW low birth weight, NBW normal birth weight, BF body fat