Table 2 List of DMRs identified between five anatomically discreet cortical regions and cerebellum
From: Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue
Start (bp) | Stop (bp) | Gene(s) | BA8 | BA9 | BA10 | EC | STG | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
p value | Δ RPKM | p value | Δ RPKM | p value | Δ RPKM | p value | Δ RPKM | p value | Δ RPKM | |||
1 | 100 | D-Loop | - | - | - | - | - | - | - | - | - | - |
101 | 200 | D-Loop | - | - | - | - | - | - | - | - | - | - |
201 | 300 | D-Loop | - | - | - | - | - | - | - | - | - | - |
301 | 400 | D-Loop | - | - | - | - | - | - | - | - | - | - |
401 | 500 | D-Loop | - | - | - | - | - | - | - | - | - | - |
501 | 600 | MT-TF | - | - | - | - | - | - | - | - | - | - |
601 | 700 | MT-TF/MT-RNR1 | - | - | - | - | - | - | - | - | - | - |
701 | 800 | MT-RNR1 | - | - | - | - | - | - | 3.21E−02 | 79156 | - | - |
801 | 900 | MT-RNR1 | 4.31E−02 | 94246 | 2.93E−02 | −43592 | - | - | - | - | 1.79E−02 | 95257 |
901 | 1000 | MT-RNR1 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
1001 | 1100 | MT-RNR1 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
1101 | 1200 | MT-RNR1 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
1201 | 1300 | MT-RNR1 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
1301 | 1400 | MT-RNR1 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
1401 | 1500 | MT-RNR1 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
1501 | 1600 | MT-RNR1 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
1601 | 1700 | MT-RNR1/MT-TV/MT-RNR2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
1701 | 1800 | MT-RNR2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
1801 | 1900 | MT-RNR2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
1901 | 2000 | MT-RNR2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
2001 | 2100 | MT-RNR2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
2101 | 2200 | MT-RNR2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
2201 | 2300 | MT-RNR2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
2301 | 2400 | MT-RNR2 | 2.54E−02 | −97351 | 3.20E−02 | −29509 | 4.31E−02 | −82048 | - | - | - | - |
2401 | 2500 | MT-RNR2 | 8.90E−03 | 70950 | - | - | - | - | - | - | - | - |
2501 | 2600 | MT-RNR2 | 3.30E−03 | 51937 | - | - | - | - | - | - | - | - |
2601 | 2700 | MT-RNR2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
2701 | 2800 | MT-RNR2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
2801 | 2900 | MT-RNR2 | - | - | - | - | - | - | - | - | - | - |
2901 | 3000 | MT-RNR2 | - | - | - | - | - | - | - | - | - | - |
3001 | 3100 | MT-RNR2 | - | - | - | - | - | - | - | - | - | - |
3101 | 3200 | MT-RNR2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
3201 | 3300 | MT-RNR2/MT-TL | - | - | - | - | - | - | 2.09E−02 | 242424 | - | - |
3301 | 3400 | MT-TL1/MT-ND1 | - | - | - | - | - | - | - | - | - | - |
3401 | 3500 | MT-ND1 | - | - | 1.54E−02 | 864685 | - | - | - | - | - | - |
3501 | 3600 | MT-ND1 | 4.41E−02 | 1180914 | - | - | 1.72E−02 | 226066 | - | - | - | - |
3601 | 3700 | MT-ND1 | 4.73E−02 | 1250436 | 4.52E−02 | 1228936 | 3.73E−02 | 1183681 | - | - | - | - |
3701 | 3800 | MT-ND1 | - | - | - | - | 2.16E−02 | 20818 | - | - | - | - |
3801 | 3900 | MT-ND1 | - | - | - | - | - | - | - | - | - | - |
3901 | 4000 | MT-ND1 | - | - | - | - | - | - | - | - | - | - |
4001 | 4100 | MT-ND1 | 2.41E−02 | −39498 | 1.55E−02 | −38704 | - | - | 4.68E−02 | −49753 | 1.56E−02 | 243767 |
4101 | 4200 | MT-ND1 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
4201 | 4300 | MT-ND1/MT-TI | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
4301 | 4400 | MT-TI/MT-TQ | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
4401 | 4500 | MT-TM/MT-ND2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
4501 | 4600 | MT-ND2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
4601 | 4700 | MT-ND2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
4701 | 4800 | MT-ND2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
4801 | 4900 | MT-ND2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
4901 | 5000 | MT-ND2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
5001 | 5100 | MT-ND2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
5101 | 5200 | MT-ND2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
5201 | 5300 | MT-ND2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
5301 | 5400 | MT-ND2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
5401 | 5500 | MT-ND2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
5501 | 5600 | MT-ND2/MT-TW/MT-TA | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
5601 | 5700 | MT-TA/MT-TN | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
5701 | 5800 | MT-TN/MT-TC | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
5801 | 5900 | MT-TC/MT-TY | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
5901 | 6000 | MT-CO1 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
6001 | 6100 | MT-CO1 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
6101 | 6200 | MT-CO1 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
6201 | 6300 | MT-CO1 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
6301 | 6400 | MT-CO1 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
6401 | 6500 | MT-CO1 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
6501 | 6600 | MT-CO1 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
6601 | 6700 | MT-CO1 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
6701 | 6800 | MT-CO1 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
6801 | 6900 | MT-CO1 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
6901 | 7000 | MT-CO1 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
7001 | 7100 | MT-CO1 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
7101 | 7200 | MT-CO1 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
7201 | 7300 | MT-CO1 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
7301 | 7400 | MT-CO1 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
7401 | 7500 | MT-CO1/MT-TS1 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
7501 | 7600 | MT-TS1/MT-TD/MT-CO2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
7601 | 7700 | MT-CO2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
7701 | 7800 | MT-CO2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
7801 | 7900 | MT-CO2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
7901 | 8000 | MT-CO2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
8001 | 8100 | MT-CO2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
8101 | 8200 | MT-CO2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
8201 | 8300 | MT-CO2/MT-TK | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
8301 | 8400 | MT-TK/MT-ATP8 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
8401 | 8500 | MT-ATP8 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
8501 | 8600 | MT-ATP8/MT-ATP6 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
8601 | 8700 | MT-ATP6 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
8701 | 8800 | MT-ATP6 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
8801 | 8900 | MT-ATP6 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
8901 | 9000 | MT-ATP6 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
9001 | 9100 | MT-ATP6 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
9101 | 9200 | MT-ATP6 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
9201 | 9300 | MT-ATP6/MT-CO3 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
9301 | 9400 | MT-CO3 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
9401 | 9500 | MT-CO3 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
9501 | 9600 | MT-CO3 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
9601 | 9700 | MT-CO3 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
9701 | 9800 | MT-CO3 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
9801 | 9900 | MT-CO3 | - | - | - | - | - | - | - | - | - | - |
9901 | 10000 | MT-CO3/MT-TG | - | - | - | - | - | - | - | - | - | - |
10001 | 10100 | MT-TG/MT-ND3 | - | - | - | - | - | - | - | - | - | - |
10101 | 10200 | MT-ND3 | - | - | - | - | - | - | - | - | - | - |
10201 | 10300 | MT-ND3 | 4.68E−02 | −662126 | - | - | - | - | 3.14E−02 | −591067 | 7.30E−03 | −57012 |
10301 | 10400 | MT-ND3/MT-TR/MT-ND4L | 3.61E−02 | −132719 | 3.61E−02 | −135759 | 4.02E−02 | −115364 | 1.40E−02 | −73063 | 3.36E−02 | −105106 |
10401 | 10500 | MT-ND4L | - | - | 4.68E−02 | −71246 | - | - | - | - | - | - |
10501 | 10600 | MT-ND4L | - | - | - | - | - | - | - | - | - | - |
10601 | 10700 | MT-ND4L | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
10701 | 10800 | MT-ND4L/MT-ND4 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
10801 | 10900 | MT-ND4 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
10901 | 11000 | MT-ND4 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
11001 | 11100 | MT-ND4 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
11101 | 11200 | MT-ND4 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
11201 | 11300 | MT-ND4 | - | - | 1.94E−02 | −68903 | 1.84E−02 | −79625 | 4.71E−02 | 58742 | - | - |
11301 | 11400 | MT-ND4 | - | - | 4.78E−02 | −139847 | - | - | - | - | - | - |
11401 | 11500 | MT-ND4 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
11501 | 11600 | MT-ND4 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
11601 | 11700 | MT-ND4 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
11701 | 11800 | MT-ND4 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
11801 | 11900 | MT-ND4 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
11901 | 12000 | MT-ND4 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
12001 | 12100 | MT-ND4 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
12101 | 12200 | MT-ND4/MT-TH | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
12201 | 12300 | MT-TS2/MT-TL2 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
12301 | 12400 | MT-TL2/MT-ND5 | 4.71E−02 | 1787 | - | −197592 | - | - | - | - | - | - |
12401 | 12500 | MT-ND5 | - | - | - | - | - | - | - | - | - | - |
12501 | 12600 | MT-ND5 | - | - | - | - | - | - | - | - | - | - |
12601 | 12700 | MT-ND5 | - | - | - | - | - | - | - | - | - | - |
12701 | 12800 | MT-ND5 | 2.05E−02 | −5702 | - | - | 4.58E−02 | −388706 | - | - | 4.36E−02 | −394978 |
12801 | 12900 | MT-ND5 | 2.26E−02 | −89668 | - | - | - | - | - | - | - | - |
12901 | 13000 | MT-ND5 | - | - | 3.10E−02 | −130016 | - | - | - | - | - | - |
13001 | 13100 | MT-ND5 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
13101 | 13200 | MT-ND5 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
13201 | 13300 | MT-ND5 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
13301 | 13400 | MT-ND5 | 1.48E−02 | −175917 | - | - | 9.80E−03 | −144949 | 3.40E−02 | −133694 | - | - |
13401 | 13500 | MT-ND5 | 3.64E−02 | −104010 | - | - | 3.40E−02 | −81264 | - | - | - | - |
13501 | 13600 | MT-ND5 | - | - | - | - | - | - | - | - | - | - |
13601 | 13700 | MT-ND5 | - | - | - | - | - | - | - | - | - | - |
13701 | 13800 | MT-ND5 | 1.31E−02 | −422610 | - | - | 1.20E−03 | 3714 | - | - | - | - |
13801 | 13900 | MT-ND5 | - | - | 3.72E−02 | 708761 | 2.59E−02 | 123249 | - | - | - | - |
13901 | 14000 | MT-ND5 | - | - | - | - | 2.17E−02 | −75118 | - | - | - | - |
14001 | 14100 | MT-ND5 | - | - | - | - | - | - | - | - | - | - |
14101 | 14200 | MT-ND5/MT-ND6 | - | - | - | - | - | - | - | - | 4.18E−02 | −534766 |
14201 | 14300 | MT-ND6 | - | - | - | - | - | - | - | - | - | - |
14301 | 14400 | MT-ND6 | - | - | - | - | - | - | - | - | - | - |
14401 | 14500 | MT-ND6 | - | - | - | - | - | - | - | - | - | - |
14501 | 14600 | MT-ND6 | - | - | - | - | - | - | - | - | 4.86E−02 | −82767 |
14601 | 14700 | MT-ND6/MT-TE | - | - | - | - | - | - | - | - | - | - |
14701 | 14800 | MT-TE/MT-CYB | - | - | - | - | - | - | - | - | - | - |
14801 | 14900 | MT-CYB | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
14901 | 15000 | MT-CYB | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
15001 | 15100 | MT-CYB | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
15101 | 15200 | MT-CYB | - | - | - | - | - | - | - | - | - | - |
15201 | 15300 | MT-CYB | - | - | - | - | - | - | 1.20E−02 | 254183 | - | - |
15301 | 15400 | MT-CYB | - | - | - | - | - | - | - | - | - | - |
15401 | 15500 | MT-CYB | 4.38E−02 | 10628 | - | - | 2.10E−02 | −554527 | - | - | 3.28E−02 | −554225 |
15501 | 15600 | MT-CYB | 3.73E−02 | −671707 | - | - | 1.23E−02 | −685630 | 3.82E−02 | 9301 | 3.51E−02 | −695515 |
15601 | 15700 | MT-CYB | - | - | - | - | 4.33E−02 | −746270 | - | - | - | - |
15701 | 15800 | MT-CYB | - | - | - | - | - | - | - | - | - | - |
15801 | 15900 | MT-CYB/MT-TT | - | - | - | - | - | - | - | - | - | - |
15901 | 16000 | MT-TT/MT-TP | - | - | - | - | - | - | - | - | - | - |
16001 | 16100 | MT-TP | - | - | - | - | - | - | - | - | - | - |
16101 | 16200 | D-Loop | - | - | 3.40E−03 | 3014 | - | - | - | - | - | - |
16201 | 16300 | D-Loop | 4.64E−02 | 380407 | 2.50E−02 | 1117943 | 3.68E−02 | 296890 | - | - | - | - |
16301 | 16400 | D-Loop | 3.65E−02 | −941720 | 1.38E−02 | −112453 | 2.73E−02 | −177146 | - | - | - | - |
16401 | 16500 | D-Loop | 4.29E−02 | 444051 | 2.20E−02 | 1151402 | 1.68E−02 | 313156 | - | - | - | - |
16501 | 16600 | D-Loop | 3.71E−02 | 784572 | 2.10E−02 | 764994 | 2.46E−02 | 836662 | - | - | - | - |