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Table 2 List of DMRs identified between five anatomically discreet cortical regions and cerebellum

From: Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue

Start (bp) Stop (bp) Gene(s) BA8 BA9 BA10 EC STG
p value Δ RPKM p value Δ RPKM p value Δ RPKM p value Δ RPKM p value Δ RPKM
1 100 D-Loop - - - - - - - - - -
101 200 D-Loop - - - - - - - - - -
201 300 D-Loop - - - - - - - - - -
301 400 D-Loop - - - - - - - - - -
401 500 D-Loop - - - - - - - - - -
501 600 MT-TF - - - - - - - - - -
601 700 MT-TF/MT-RNR1 - - - - - - - - - -
701 800 MT-RNR1 - - - - - - 3.21E−02 79156 - -
801 900 MT-RNR1 4.31E−02 94246 2.93E−02 −43592 - - - - 1.79E−02 95257
901 1000 MT-RNR1 ND ND ND ND ND ND ND ND ND ND
1001 1100 MT-RNR1 ND ND ND ND ND ND ND ND ND ND
1101 1200 MT-RNR1 ND ND ND ND ND ND ND ND ND ND
1201 1300 MT-RNR1 ND ND ND ND ND ND ND ND ND ND
1301 1400 MT-RNR1 ND ND ND ND ND ND ND ND ND ND
1401 1500 MT-RNR1 ND ND ND ND ND ND ND ND ND ND
1501 1600 MT-RNR1 ND ND ND ND ND ND ND ND ND ND
1601 1700 MT-RNR1/MT-TV/MT-RNR2 ND ND ND ND ND ND ND ND ND ND
1701 1800 MT-RNR2 ND ND ND ND ND ND ND ND ND ND
1801 1900 MT-RNR2 ND ND ND ND ND ND ND ND ND ND
1901 2000 MT-RNR2 ND ND ND ND ND ND ND ND ND ND
2001 2100 MT-RNR2 ND ND ND ND ND ND ND ND ND ND
2101 2200 MT-RNR2 ND ND ND ND ND ND ND ND ND ND
2201 2300 MT-RNR2 ND ND ND ND ND ND ND ND ND ND
2301 2400 MT-RNR2 2.54E02 −97351 3.20E02 −29509 4.31E02 −82048 - - - -
2401 2500 MT-RNR2 8.90E−03 70950 - - - - - - - -
2501 2600 MT-RNR2 3.30E−03 51937 - - - - - - - -
2601 2700 MT-RNR2 ND ND ND ND ND ND ND ND ND ND
2701 2800 MT-RNR2 ND ND ND ND ND ND ND ND ND ND
2801 2900 MT-RNR2 - - - - - - - - - -
2901 3000 MT-RNR2 - - - - - - - - - -
3001 3100 MT-RNR2 - - - - - - - - - -
3101 3200 MT-RNR2 ND ND ND ND ND ND ND ND ND ND
3201 3300 MT-RNR2/MT-TL - - - - - - 2.09E−02 242424 - -
3301 3400 MT-TL1/MT-ND1 - - - - - - - - - -
3401 3500 MT-ND1 - - 1.54E−02 864685 - - - - - -
3501 3600 MT-ND1 4.41E−02 1180914 - - 1.72E−02 226066 - - - -
3601 3700 MT-ND1 4.73E02 1250436 4.52E02 1228936 3.73E02 1183681 - - - -
3701 3800 MT-ND1 - - - - 2.16E−02 20818 - - - -
3801 3900 MT-ND1 - - - - - - - - - -
3901 4000 MT-ND1 - - - - - - - - - -
4001 4100 MT-ND1 2.41E−02 −39498 1.55E−02 −38704 - - 4.68E−02 −49753 1.56E−02 243767
4101 4200 MT-ND1 ND ND ND ND ND ND ND ND ND ND
4201 4300 MT-ND1/MT-TI ND ND ND ND ND ND ND ND ND ND
4301 4400 MT-TI/MT-TQ ND ND ND ND ND ND ND ND ND ND
4401 4500 MT-TM/MT-ND2 ND ND ND ND ND ND ND ND ND ND
4501 4600 MT-ND2 ND ND ND ND ND ND ND ND ND ND
4601 4700 MT-ND2 ND ND ND ND ND ND ND ND ND ND
4701 4800 MT-ND2 ND ND ND ND ND ND ND ND ND ND
4801 4900 MT-ND2 ND ND ND ND ND ND ND ND ND ND
4901 5000 MT-ND2 ND ND ND ND ND ND ND ND ND ND
5001 5100 MT-ND2 ND ND ND ND ND ND ND ND ND ND
5101 5200 MT-ND2 ND ND ND ND ND ND ND ND ND ND
5201 5300 MT-ND2 ND ND ND ND ND ND ND ND ND ND
5301 5400 MT-ND2 ND ND ND ND ND ND ND ND ND ND
5401 5500 MT-ND2 ND ND ND ND ND ND ND ND ND ND
5501 5600 MT-ND2/MT-TW/MT-TA ND ND ND ND ND ND ND ND ND ND
5601 5700 MT-TA/MT-TN ND ND ND ND ND ND ND ND ND ND
5701 5800 MT-TN/MT-TC ND ND ND ND ND ND ND ND ND ND
5801 5900 MT-TC/MT-TY ND ND ND ND ND ND ND ND ND ND
5901 6000 MT-CO1 ND ND ND ND ND ND ND ND ND ND
6001 6100 MT-CO1 ND ND ND ND ND ND ND ND ND ND
6101 6200 MT-CO1 ND ND ND ND ND ND ND ND ND ND
6201 6300 MT-CO1 ND ND ND ND ND ND ND ND ND ND
6301 6400 MT-CO1 ND ND ND ND ND ND ND ND ND ND
6401 6500 MT-CO1 ND ND ND ND ND ND ND ND ND ND
6501 6600 MT-CO1 ND ND ND ND ND ND ND ND ND ND
6601 6700 MT-CO1 ND ND ND ND ND ND ND ND ND ND
6701 6800 MT-CO1 ND ND ND ND ND ND ND ND ND ND
6801 6900 MT-CO1 ND ND ND ND ND ND ND ND ND ND
6901 7000 MT-CO1 ND ND ND ND ND ND ND ND ND ND
7001 7100 MT-CO1 ND ND ND ND ND ND ND ND ND ND
7101 7200 MT-CO1 ND ND ND ND ND ND ND ND ND ND
7201 7300 MT-CO1 ND ND ND ND ND ND ND ND ND ND
7301 7400 MT-CO1 ND ND ND ND ND ND ND ND ND ND
7401 7500 MT-CO1/MT-TS1 ND ND ND ND ND ND ND ND ND ND
7501 7600 MT-TS1/MT-TD/MT-CO2 ND ND ND ND ND ND ND ND ND ND
7601 7700 MT-CO2 ND ND ND ND ND ND ND ND ND ND
7701 7800 MT-CO2 ND ND ND ND ND ND ND ND ND ND
7801 7900 MT-CO2 ND ND ND ND ND ND ND ND ND ND
7901 8000 MT-CO2 ND ND ND ND ND ND ND ND ND ND
8001 8100 MT-CO2 ND ND ND ND ND ND ND ND ND ND
8101 8200 MT-CO2 ND ND ND ND ND ND ND ND ND ND
8201 8300 MT-CO2/MT-TK ND ND ND ND ND ND ND ND ND ND
8301 8400 MT-TK/MT-ATP8 ND ND ND ND ND ND ND ND ND ND
8401 8500 MT-ATP8 ND ND ND ND ND ND ND ND ND ND
8501 8600 MT-ATP8/MT-ATP6 ND ND ND ND ND ND ND ND ND ND
8601 8700 MT-ATP6 ND ND ND ND ND ND ND ND ND ND
8701 8800 MT-ATP6 ND ND ND ND ND ND ND ND ND ND
8801 8900 MT-ATP6 ND ND ND ND ND ND ND ND ND ND
8901 9000 MT-ATP6 ND ND ND ND ND ND ND ND ND ND
9001 9100 MT-ATP6 ND ND ND ND ND ND ND ND ND ND
9101 9200 MT-ATP6 ND ND ND ND ND ND ND ND ND ND
9201 9300 MT-ATP6/MT-CO3 ND ND ND ND ND ND ND ND ND ND
9301 9400 MT-CO3 ND ND ND ND ND ND ND ND ND ND
9401 9500 MT-CO3 ND ND ND ND ND ND ND ND ND ND
9501 9600 MT-CO3 ND ND ND ND ND ND ND ND ND ND
9601 9700 MT-CO3 ND ND ND ND ND ND ND ND ND ND
9701 9800 MT-CO3 ND ND ND ND ND ND ND ND ND ND
9801 9900 MT-CO3 - - - - - - - - - -
9901 10000 MT-CO3/MT-TG - - - - - - - - - -
10001 10100 MT-TG/MT-ND3 - - - - - - - - - -
10101 10200 MT-ND3 - - - - - - - - - -
10201 10300 MT-ND3 4.68E−02 −662126 - - - - 3.14E−02 −591067 7.30E−03 −57012
10301 10400 MT-ND3/MT-TR/MT-ND4L 3.61E02 −132719 3.61E02 −135759 4.02E02 −115364 1.40E−02 −73063 3.36E−02 −105106
10401 10500 MT-ND4L - - 4.68E−02 −71246 - - - - - -
10501 10600 MT-ND4L - - - - - - - - - -
10601 10700 MT-ND4L ND ND ND ND ND ND ND ND ND ND
10701 10800 MT-ND4L/MT-ND4 ND ND ND ND ND ND ND ND ND ND
10801 10900 MT-ND4 ND ND ND ND ND ND ND ND ND ND
10901 11000 MT-ND4 ND ND ND ND ND ND ND ND ND ND
11001 11100 MT-ND4 ND ND ND ND ND ND ND ND ND ND
11101 11200 MT-ND4 ND ND ND ND ND ND ND ND ND ND
11201 11300 MT-ND4 - - 1.94E−02 −68903 1.84E−02 −79625 4.71E−02 58742 - -
11301 11400 MT-ND4 - - 4.78E−02 −139847 - - - - - -
11401 11500 MT-ND4 ND ND ND ND ND ND ND ND ND ND
11501 11600 MT-ND4 ND ND ND ND ND ND ND ND ND ND
11601 11700 MT-ND4 ND ND ND ND ND ND ND ND ND ND
11701 11800 MT-ND4 ND ND ND ND ND ND ND ND ND ND
11801 11900 MT-ND4 ND ND ND ND ND ND ND ND ND ND
11901 12000 MT-ND4 ND ND ND ND ND ND ND ND ND ND
12001 12100 MT-ND4 ND ND ND ND ND ND ND ND ND ND
12101 12200 MT-ND4/MT-TH ND ND ND ND ND ND ND ND ND ND
12201 12300 MT-TS2/MT-TL2 ND ND ND ND ND ND ND ND ND ND
12301 12400 MT-TL2/MT-ND5 4.71E−02 1787 - −197592 - - - - - -
12401 12500 MT-ND5 - - - - - - - - - -
12501 12600 MT-ND5 - - - - - - - - - -
12601 12700 MT-ND5 - - - - - - - - - -
12701 12800 MT-ND5 2.05E−02 −5702 - - 4.58E−02 −388706 - - 4.36E−02 −394978
12801 12900 MT-ND5 2.26E−02 −89668 - - - - - - - -
12901 13000 MT-ND5 - - 3.10E−02 −130016 - - - - - -
13001 13100 MT-ND5 ND ND ND ND ND ND ND ND ND ND
13101 13200 MT-ND5 ND ND ND ND ND ND ND ND ND ND
13201 13300 MT-ND5 ND ND ND ND ND ND ND ND ND ND
13301 13400 MT-ND5 1.48E−02 −175917 - - 9.80E−03 −144949 3.40E−02 −133694 - -
13401 13500 MT-ND5 3.64E−02 −104010 - - 3.40E−02 −81264 - - - -
13501 13600 MT-ND5 - - - - - - - - - -
13601 13700 MT-ND5 - - - - - - - - - -
13701 13800 MT-ND5 1.31E−02 −422610 - - 1.20E−03 3714 - - - -
13801 13900 MT-ND5 - - 3.72E−02 708761 2.59E−02 123249 - - - -
13901 14000 MT-ND5 - - - - 2.17E−02 −75118 - - - -
14001 14100 MT-ND5 - - - - - - - - - -
14101 14200 MT-ND5/MT-ND6 - - - - - - - - 4.18E−02 −534766
14201 14300 MT-ND6 - - - - - - - - - -
14301 14400 MT-ND6 - - - - - - - - - -
14401 14500 MT-ND6 - - - - - - - - - -
14501 14600 MT-ND6 - - - - - - - - 4.86E−02 −82767
14601 14700 MT-ND6/MT-TE - - - - - - - - - -
14701 14800 MT-TE/MT-CYB - - - - - - - - - -
14801 14900 MT-CYB ND ND ND ND ND ND ND ND ND ND
14901 15000 MT-CYB ND ND ND ND ND ND ND ND ND ND
15001 15100 MT-CYB ND ND ND ND ND ND ND ND ND ND
15101 15200 MT-CYB - - - - - - - - - -
15201 15300 MT-CYB - - - - - - 1.20E−02 254183 - -
15301 15400 MT-CYB - - - - - - - - - -
15401 15500 MT-CYB 4.38E−02 10628 - - 2.10E−02 −554527 - - 3.28E−02 −554225
15501 15600 MT-CYB 3.73E−02 −671707 - - 1.23E−02 −685630 3.82E−02 9301 3.51E−02 −695515
15601 15700 MT-CYB - - - - 4.33E−02 −746270 - - - -
15701 15800 MT-CYB - - - - - - - - - -
15801 15900 MT-CYB/MT-TT - - - - - - - - - -
15901 16000 MT-TT/MT-TP - - - - - - - - - -
16001 16100 MT-TP - - - - - - - - - -
16101 16200 D-Loop - - 3.40E−03 3014 - - - - - -
16201 16300 D-Loop 4.64E02 380407 2.50E02 1117943 3.68E02 296890 - - - -
16301 16400 D-Loop 3.65E02 −941720 1.38E02 −112453 2.73E02 −177146 - - - -
16401 16500 D-Loop 4.29E02 444051 2.20E02 1151402 1.68E02 313156 - - - -
16501 16600 D-Loop 3.71E02 784572 2.10E02 764994 2.46E02 836662 - - - -
  1. Shown is the location of the DMR within the mitochondrial genome (ChrM) (based on GENCODE), the gene(s) residing within the 100 bp window, and p value from paired t tests between each of the five cortical regions: Brodmann areas 8, 9 and 10 (BA8, BA9, BA10), entorhinal cortex (ECX) and superior temporal gyrus (STG) compared to the cerebellum (CER). Results are displayed in order of genomic position. RPKM and corresponding p values are shown for windows if p < 0.05. Key: - denotes data not significant (p > 0.05); ND denotes not determined as the window was not included in analysis due to removal in NUMT pipeline. Results shown in bold represent those found to be present across all prefrontal cortex areas (BA8, BA9, BA10)