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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue

Fig. 3

DNA methylation differences are seen in the mitochondrial genome between brain regions and blood. Average raw RPKM values across the mitochondrial genome for each individual cortical brain region alongside matched blood and cerebellum samples are shown in the top panel, with gene positions downloaded from GENCODE shown in the middle panel. For each 100 bp window, paired t tests were performed to compare each cortical brain region and the cerebellum, with -log10 (p) shown in the bottom panel. BLD blood, BA8 Brodmann area 8, BA9 Brodmann area 9, BA10 Brodmann area 10, CER cerebellum, CTX cortex, ECX entorhinal cortex, RPKM reads per kilobase of transcript per million mapped reads, STG superior temporal gyrus. Red dashed line denotes the Bonferroni significance, whilst blue dashed line denotes p < 0.05 in the lower panel

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