Table 5 Top diseases and biological functions associated with differentially methylated genes between smokers vs. non-smokers

Diseases and disorders

P value

No. of molecules

Hereditary disorder

1.44E-02–8.85E-05

3

Organismal injury and abnormalities

4.84E-02–8.85E-05

8

Renal and urological disease

2.82E-02–8.85E-05

2

Cancer

4.84E-02–3.80E-04

8

Cardiovascular disease

3.45E-02–3.803E-04

1

Molecular and cellular functions

P value

No. of molecules

Cell morphology

3.48E-02–3.80E-04

2

Cell-to-cell signaling and interaction

4.07E-02–3.80E-04

2

Cellular assembly and organization

4.44E-02–3.80E-04

3

Cell cycle

3.42E-03–7.61E-04

2

Cell death and survival

4.45E-02–7.61E-04

2

Physiological system development and function

P value

No. of molecules

Cardiovascular system development and function

4.07E-02–3.80E-04

3

Embryonic development

3.26E-02–3.80E-04

4

Lymphoid tissue structure and development

6.07E-02–3.80E-04

1

Organismal development

2.67E-02–3.80E-04

3

Organ morphology

2.52E-02–3.80E-04

3