Fig. 4
From: DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD
Differentially methylated CpG sites associated with smokers. Differential methylation analysis revealed CpG sites in genes significantly associated with smokers with a P value less than 0.05. Difference in mean beta values represents the difference in mean methylation between smokers and non-smokers (controls). The y axis represents the beta value. The gene symbol associated with CpG probes are provided in parenthesis. Data are represented as a box plot which displays the full range of variation (from min to max), the likely range of variation (the IQR) and a typical value (the median) for n = 8/group, and the significance determined using one-way ANOVA (Tukey’s multiple comparisons test). *P < 0.05, **P < 0.01, ***P < 0.001, vs. non-smokers; ### P < 0.001 vs. smokers