From: Aberrant DNA methylation in melanoma: biomarker and therapeutic opportunities
Gene name | Function | Methylation prevalence (%) | Methylation context | Associated changes | Reference |
---|---|---|---|---|---|
PTEN | Inhibitor of PI3K signaling | 6–62 | Promoter hypermethylation | Gene transcription silenced | |
p16 | Inhibitor of CDK4/6 | 5–27 | Promoter hypermethylation | NRAS mutation associated | |
p14 | Inhibitor of MDM2 | 41–57 | Promoter hypermethylation | Gene transcription decreased | |
RASSF1A | Cell cycle regulator | 15–57 | Promoter hypermethylation | Loss of expression | |
MGMT | DNA repair | 35 | Promoter hypermethylation | No correlation | [150] |