The dynamic DNA methylation landscape of the mutL homolog 1 shore is altered by MLH1-93G>A polymorphism in normal tissues and colorectal cancer

Table 2 Multiple linear regression model for all DNA sources as well as PBMC, normal colorectal mucosa, and CRC tumour DNA

	All DNA sources		PBMC		Normal colon		Tumour
Variable	r	P	r	P	r	P	r	P
Tissue	0.06	0.07
rs1800734	−0.07	0.045	−0.14	0.02	−0.15	0.01	0.03	0.58
Age	0.07	0.05	−0.05	0.28	0.19	0.001	0.04	0.36
Sex	0.0002	0.78	0.06	0.47	0.003	0.77	−0.04	0.54
Stage	−0.01	0.79	0.11	0.07	0.13	0.04	−0.14	0.02
MSI status	0.03	0.93	0.05	0.48	0.04	0.91	0.01	0.70
MLH1 CpG island methylation	−0.03	0.49	−0.02	0.60	−0.02	0.57	−0.04	0.39

ISSN: 1868-7083