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Table 2 Intake of maternal methyl-group donors through diet and supplements (folic acid) during pregnancy and in the postpartum (PP) period

From: Maternal intake of methyl-group donors affects DNA methylation of metabolic genes in infants

Methyl-group donors First trimester (10–13 weeks)
Mean (SE)
Range
N = 94
Second trimester (18–22 weeks)
Mean (SE)
Range
N = 85
Third trimester (30–34 weeks)
Mean (SE)
Range
N = 82
6–8 weeks PP
Mean (SE)
Range
N = 79
6 months PP
Mean (SE)
Range
N = 60
p Dietary guidelines
Methionine (mg)
(mg/kg)
1644.4 (45.9)
792–2932
12.4–45.1
1608.4 (44.3)
746.1–2684.4
9.6–38
1659.3 (48.7)
789–2957
9.2–40.6
1678.5 (52)
786.4–3499.4
12.5–45.8
1562.4a (43.5)
710.5–2562.8
11.7–35.1
0.047 Daily requirement
10.4 mg/kg body weight
Folate (μg) 272.1 (8.7)
131–531
263.2 (8.8)
98–519.8
279.8 (10.5)
112–619
264 (9)
97.4–520.7
263.7 (10.7)
98–564.4
0.17 Recommended intake
Non-pregnant 200-300
Pregnant 400
Lactation 300
Folic acid (μg) 507.2b (14.1)
171–1000
399.9 (23.9)
0–1000
391.3 (25.6)
0–1000
204.3c (24.7)
0–800
68c (14.9)
0–600
0.000
Choline (mg) 274.4 (7.4)
137–451
268.1 (7.4)
137.3–469.2
280.3 (8.6)
130–552
278.2 (8.5)
128.3–547.4
268.4 (7.8)
115.3–435.5
0.26 Adequate intake
Non-pregnant 400
Pregnant 450
Lactation 550
Betaine (mg) 162.6 (5.7)
63–342
169.2 (6.2)
52.6–354.3
173.2 (6.7)
68–320
170.2 (6.5)
80–349.3
162.6 (7.2)
34.5–326.2
0.53 /
  1. p values were obtained using a multivariate regression model for longitudinal measurements
  2. aMethionine intake 6 months PP was significantly lower than the intake in the third trimester of pregnancy and 6–8 weeks PP
  3. bFolic acid intake was significantly higher in the first trimester of pregnancy compared to the other time points
  4. cFolic acid intake in the PP period was significantly lower than the intake during pregnancy and within the PP period, folic acid intake 6 months PP was lower