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Table 5 Sex differences for LINE1 methylation pyrosequencing assay

From: Global DNA methylation levels are altered by modifiable clinical manipulations in assisted reproductive technologies

Cohort Group Males Females P valuesa
Number of placentas Global methylation fraction (mean ± SD) Number of placentas Global methylation fraction (mean ± SD)
Original cohort Controls 33 0.5091 ± 0.0463 32 0.4902 ± 0.0448 0.0494
ART 56 0.4785 ± 0.0402 70 0.4791 ± 0.0503 0.4727
Validation cohort Controls 29 0.4266 ± 0.0401 28 0.3936 ± 0.0583 0.0078
ART 26 0.4227 ± 0.0382 29 0.4386 ± 0.09538 0.2149
Opposite sex twins ART 39 0.4076 ± 0.0294 39 0.4098 ± 0.0320 0.3199
  1. ART assisted reproductive technology; SD standard deviation
  2. aUnpaired one-tailed t test
  3. Values in italics denote significance [59]