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Table 1 Demographic profile and clinical characteristics of the study subjects

From: Global DNA methylation levels are altered by modifiable clinical manipulations in assisted reproductive technologies

  Original cohort Validation cohort Twin cohort
ART (n = 182) Controls (n = 77) P value ART (n = 55) Controls (n = 57) P value ART (n = 39 pairs)
Maternal age (years, mean ± SD) 34.7 ± 3.6 32.2 ± 4.8 < 0.0001 a 35.8 ± 3.9 29.5 ± 6.1 < 0.0001 a 37.2 ± 5.2
Paternal age (years, mean ± SD) 36.9 ± 5.7 33.3 ± 5.2 < 0.0001 a 38.3 ± 6.5 34.8 ± 4.6 0.0610 39.0 ± 6.9
Mode of egg fertilization (ICSI/non ICSI) 54/127 NA 30/23 NA 14/24
Oxygen tension (20/5%) 123/59 NA 16/38 NA 19/19
Type of embryo transfer (fresh/frozen) 128/54 NA 33/22 NA 26/13
Embryo transfer day (day 3/day 5) 110/72 NA 17/37 NA 18/20
Gestational age (weeks, mean ± SD) 39.2 ± 1.3 39.1 ± 1.2 0.4306a 38.2 ± 3.6 38.2 ± 6.4 0.9990a 36.5 ± 2.1
Birth weight (grams, mean ± SD) 3441.5 ± 498.6 3318.8 ± 559.3 0.0837a 3196 ± 918.4 3411 ± 541.7 0.1324a 2653.1 ± 576.9
Males (%) 83(45.6) 39 (50.6) 0.4972b 26 29 0.7103b 39(50.0)
Females (%) 99(54.4) 38 (49.4) 29 28 39(50.0)
  1. ART assisted reproductive technology; SD standard deviation;
  2. ICSI intracytoplasmic sperm injection; NA not applicable
  3. aUnpaired two-tailed t test
  4. bFisher’s exact test
  5. Values in italics denote significance