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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Medulloblastoma and ependymoma cells display increased levels of 5-carboxylcytosine and elevated TET1 expression

Fig. 4

5caC enrichment correlates with elevated levels of TET1 transcript in paediatric brain tumour cell lines. a Overlays of 5hmC (left) and 5caC (right) signal intensity profiles for representative nuclear regions of the indicated paediatric brain tumour cells. Signal intensity profiles for DKFZ-EP1NS cells with high/detectable (DKFZ-EP1NS H) and low/undetectable (DKFZ-EP1NS L) 5caC signals are shown separately. b Quantification of 5hmC and 5caC signals in the indicated ependymoma and medulloblastoma cell lines. Mean values of the average intensities of eight signal intensity profiles for each cell line/population are shown. DKFZ-EP1NS H cells with high/detectable 5caC, DKFZ-EP1NS L cells with low/undetectable 5caC. ***p < 0.001; **p < 0.01; *p < 0.05; ns not significant. c Relative expression of Tet1/2/3 and TDG transcripts in the indicated paediatric brain tumour cell lines and HeLa cells. Experimental error is shown as SEM

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