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Table 3 Associations between genome-wide DNA methylation and lipid levels (meta-analyses)

From: Epigenome-wide association study (EWAS) on lipids: the Rotterdam Study

   Model 2a Model 3b   Model 4c   
  ProbeID Regression coefficient p d Regression coefficient p d Regression coefficient p d Gene
TG cg00574958 −0.0142 2.6 × 10 −26 −0.0114 1.9 × 10 −16 −0.0161 1.5 × 10 −22 CPT1A
  cg06500161 0.0167 1.4 × 10 −24 0.0153 3.9 × 10 −18 0.0151 7.0 × 10 −14 ABCG1
  cg11024682 0.0147 3.0 × 10 −19 0.0124 8.4 × 10 −13 0.0138 1.0 × 10 −11 SREBF1
  cg17058475 −0.0146 3.1 × 10 −13 −0.0120 8.8 × 10 −09 −0.0196 9.2 × 10 −16 CPT1A
  cg17901584 −0.013 1.9 × 10 −08 −0.0104 2.5 × 10 −05 −0.012 2.5 × 10 −05 DHCR24
HDL-C cg06500161 −0.0187 9.5 × 10 −23 −0.0166 9.5 × 10 −16 −0.0116 2.5 × 10 −07 ABCG1
  cg14816825 −0.0104 3.2 × 10 −07 −0.0145 3.8 × 10 −07 −0.0127 1.7 × 10 −07 NA e
  cg17901584 0.0164 2.4 × 10 −09 0.0128 1.3 × 10 −05 0.0116 3.6 × 10 −04 DHCR24
  1. All models are adjusted for age, gender, current smoking, leukocyte proportions, array number, and position on array
  2. Values are regression coefficients based on linear mixed models and reflect differences in methylation beta values per increase in HDL-C or log-transformed triglyceride unit
  3. aModel 2: model 1 + lipid-lowering medication use
  4. bModel 3: model 1 + waist circumference
  5. cModel 4: model 1 + other lipids
  6. d P values in italic indicate statistical significance. Level of significance: p < 7.14 × 10−03
  7. eNot annotated