Table 6 Association between selected SNPs in each age acceleration locus and WMH burden in 17,936 middle-aged to elderly participants from the NeuroCHARGE consortium
SNP | Chromosome | Coded allele | Coded allele frequency (AA/EA) | P value (direction) of association with Hannum age acceleration | P value (direction) of association with Horvath age acceleration | P value (direction) of association with WMH burden | |
|---|---|---|---|---|---|---|---|
European | African-American | ||||||
rs6703462 | 1q24 | T | 0.16/0.08 | 1.5 × 10−9 (+) | 0.0097 (+) | 0.029 (−) | 0.20 (+) |
rs4635894 | 5q12 | T | 0.06/0.07 | 3.0 × 10−8 (+) | 0.0011 (+) | 0.55 (+) | 0.52 (−) |
rs75407001 | 6p22 | T | 0.08/0.04 | 0.26 (−) | 1 × 10−11 (−) | 0.19 (−) | 0.68 (+) |
rs140625670 | 17q11 | C | 0.01/NA | 0.01 (−) | 4.3 × 10−8 (−) | NA | 0.29 (−) |