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Table 6 Association between selected SNPs in each age acceleration locus and WMH burden in 17,936 middle-aged to elderly participants from the NeuroCHARGE consortium

From: Cerebral white matter hyperintensities on MRI and acceleration of epigenetic aging: the atherosclerosis risk in communities study

SNP Chromosome Coded allele Coded allele frequency (AA/EA) P value (direction) of association with Hannum age acceleration P value (direction) of association with Horvath age acceleration P value (direction) of association with WMH burden
European African-American
rs6703462 1q24 T 0.16/0.08 1.5 × 10−9 (+) 0.0097 (+) 0.029 (−) 0.20 (+)
rs4635894 5q12 T 0.06/0.07 3.0 × 10−8 (+) 0.0011 (+) 0.55 (+) 0.52 (−)
rs75407001 6p22 T 0.08/0.04 0.26 (−) 1 × 10−11 (−) 0.19 (−) 0.68 (+)
rs140625670 17q11 C 0.01/NA 0.01 (−) 4.3 × 10−8 (−) NA 0.29 (−)