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Table 4 Association between WMH burden and age acceleration estimates

From: Cerebral white matter hyperintensities on MRI and acceleration of epigenetic aging: the atherosclerosis risk in communities study

 

Horvath predictor

Hannum et al. predictor

 

Beta (SD)a

P value

% variance explained

Beta (SD)a

P value

% variance explained

Model 1

0.007 (0.003)

0.0287

0.61

0.011 (0.003)

0.0005

1.51

Model 2

0.007 (0.003)

0.0134

0.74

0.009 (0.003)

0.0044

1.12

Model 3

0.007 (0.003)

0.0258

0.60

0.009 (0.003)

0.0162

0.69

  1. Model 1: adjusted for age at brain MRI and sex. Model 2: adjusted for age at brain MRI, sex, body mass index, systolic blood pressure, hypertension, diabetes, and current smoking. Model 3: adjusted for covariates in model 2 and white blood cell composition
  2. SD standard deviation
  3. aWMH grade unit
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Clinical Epigenetics

ISSN: 1868-7083

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