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Table 4 Association between WMH burden and age acceleration estimates

From: Cerebral white matter hyperintensities on MRI and acceleration of epigenetic aging: the atherosclerosis risk in communities study

  Horvath predictor Hannum et al. predictor
  Beta (SD)a P value % variance explained Beta (SD)a P value % variance explained
Model 1 0.007 (0.003) 0.0287 0.61 0.011 (0.003) 0.0005 1.51
Model 2 0.007 (0.003) 0.0134 0.74 0.009 (0.003) 0.0044 1.12
Model 3 0.007 (0.003) 0.0258 0.60 0.009 (0.003) 0.0162 0.69
  1. Model 1: adjusted for age at brain MRI and sex. Model 2: adjusted for age at brain MRI, sex, body mass index, systolic blood pressure, hypertension, diabetes, and current smoking. Model 3: adjusted for covariates in model 2 and white blood cell composition
  2. SD standard deviation
  3. aWMH grade unit