Table 1 TET and IDH gene mutation analysis in 218 CLL patients
Position/mutation | Type | Consequence |
|---|---|---|
TET1 | ||
 chr10:g.70318749T>A | Single base substitution | Upstream |
 chr10:g.70333015C>A | Single base substitution | Missense: P307H |
 chr10:g.70413592G>A | Single base substitution | Intron |
 chr10:g.70346080G>A | Single base substitution | Intron |
 chr10:g.70447656G>A | Single base substitution | Intron |
 chr10:g.70360941C>G | Single base substitution | Intron |
TET2 | ||
 chr4:g.106161089G>A | Single base substitution | 3 UTR | intron |
 chr4:g.106196355C>T | Single base substitution | Missense: S1563F, S1584F | 3 UTR |
 chr4:g.106175952A>C | Single base substitution | Intron |
 chr4:g.106075153G>A | Single base substitution | Intron |
 chr4:g.106108570A>T | Single base substitution | Intron |
 chr4:g.106087334A>C | Single base substitution | Intron |
 chr4:g.106064903T>A | Single base substitution | Upstream: AC004069.2 |
TET3 | ||
 chr2:g.74276067C>A | Single base substitution | Downstream | intron |
 chr2:g.74226519->A | Insertion of ≤200 bp | Upstream |
 chr2:g.74300784G>A | Single base substitution | Exon | intron |
 chr2:g.74247963G>A | Single base substitution | Intron |
 chr2:g.74274651G>A | Single base substitution | Missense: R443H, R401H | Exon |
 chr2:g.74238478A>T | Single base substitution | Intron |
 chr2:g.74278374G>A | Single base substitution | Downstream |
IDH1 | ||
 chr2:g.209111428G>A | Single base substitution | Downstream | intron |
 chr2:g.209123819C>T | Single base substitution | Upstream | downstream IDH1-AS1| intron |
 chr2:g.209135430A>G | Single base substitution | Upstream-AC016697.2 | intron: PIKFYVE |
 chr2:g.209121002T>G | Single base substitution | Upstream | downstream: IDH1-AS1 | intron |
 chr2:g.209102172T>C | Single base substitution | Upstream: AC016697.3 | intron |
IDH2 | ||
 chr15:g.90631755C>T | Single base substitution | Intron |
 chr15:g.90631061C>A | Single base substitution | Intron |