Epigenome-wide association data implicates DNA methylation-mediated genetic risk in psoriasis

Clinical Epigenetics

Table 1 Methylation sites mediate genetic risks in psoriasis

Psoriasis associated DMSs					SNPs associated with DMSs
Illumina ID*	Gene_context	Gene name	P value (Meth vs. Pheno)	Beta difference	SNP	Map	Nearby gene	P value (Geno vs. Pheno)	Adjusted P value (Meth vs. Geno)	Adjusted independent P value (Geno vs. Pheno)	CIT P†
cg04087571	Body	SIK3	1.69E−10	−0.11	rs13203895	31276305	USP8P1	4.80E−08	0.022	0.004	0.022
cg04087571	Body	SIK3	1.69E−10	−0.11	rs2853953	31267728	HLA-C	2.77E−08	0.024	0.010	0.024
cg04087571	Body	SIK3	1.69E−10	−0.11	rs10484554	31306778	WASF5P	2.54E−08	0.027	0.005	0.027
cg04087571	Body	SIK3	1.69E−10	−0.11	rs2245822	31263023	HLA-C	1.83E−08	0.027	0.010	0.027
cg04087571	Body	SIK3	1.69E−10	−0.11	rs2853952	31268092	HLA-C	2.54E−08	0.027	0.008	0.027
cg09914444	TSS1500	DMBX1	1.47E−10	−0.11	rs13203895	31276305	USP8P1	4.80E−08	0.034	0.027	0.034
cg09914444	TSS1500	DMBX1	1.47E−10	−0.11	rs2245822	31263023	HLA-C	1.83E−08	0.037	0.037	0.037
cg09914444	TSS1500	DMBX1	1.47E−10	−0.11	rs10484554	31306778	WASF5P	2.54E−08	0.042	0.030	0.042
cg06834507	Body	C1orf106	5.00E−12	−0.11	rs13203895	31276305	USP8P1	4.80E−08	0.046	0.005	0.046
cg06834507	Body	C1orf106	5.00E−12	−0.11	rs2853953	31267728	HLA-C	2.77E−08	0.047	0.007	0.047
cg09914444	TSS1500	DMBX1	1.47E−10	−0.11	rs2853953	31267728	HLA-C	2.77E−08	0.041	0.047	0.047

Gene name: According to HUGO Gene Nomenclature Committee; Gene_context: Location of the gene associated CpG-site(s) with respect to the gene context
*Illumina ID is arranged by significance rank of CIT test
†CIT P: the maximum of the component P-values for an omnibus test

ISSN: 1868-7083