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Table 4 Variables included in the study

From: Cell-free DNA promoter hypermethylation in plasma as a diagnostic marker for pancreatic adenocarcinoma

 

OR

95% CI

p value

AUC

ALX4

4.29

(1.62; 11.35)

0.0034

0.57

APC

4.16

(2.21; 7.84)

9.67 × 10 −6

0.65

BMP3

7.37

(3.20; 16.95)

2.64 × 10 −6

0.64

BNC1

9.32

(3.90; 22.25)

5.02 × 10 −7

0.65

BRCA1

1.21

(0.49; 2.98)

0.6804

0.51

CDKN2A

2.27

(0.66; 11.17)

0.1652

0.52

CDKN2B

2.42

(0.91; 6.40)

0.0757

0.53

CHFR

0.43

(0.04; 4.19)

0.4668

0.51

ESR1

2.23

(1.22; 4.07)

0.0095

0.58

EYA2

2.30

(0.91; 5.80)

0.0778

0.54

GSTP1

4.01

(0.41; 39.18)

0.2323

0.51

HIC1

3.69

(1.37; 9.91)

0.0097

0.55

MESTv2

2.99

(1.63; 5.49)

0.0004

0.62

MGMT

2.24

(0.52; 9.62)

0.2778

0.51

MLH1

1.48

(0.66; 3.31)

0.3448

0.52

NPTX2

3.37

(1.88; 6.02)

4.34 × 10 −5

0.64

NEUROG1

1.50

(0.59; 3.86)

0.3969

0.52

RARB

1.81

(1.04; 3.15)

0.0348

0.57

RASSF1A

5.28

(2.69; 10.39)

1.4 × 10 −6

0.65

SFRP1

3.30

(1.81; 6.03)

0.0001

0.62

SFRP2

2.00

(1.12; 3.58)

0.0197

0.57

SEPT9v2

6.97

(1.94; 25.03)

0.0029

0.56

SST

3.04

(1.75; 5.30)

8.69 × 10 −5

0.64

TFPI2

12.16

(3.51; 42.04)

7.96 × 10 −5

0.60

TAC1

3.25

(1.86; 5.69)

3.63 × 10 −5

0.64

VIM

a

WNT5A

11.31

(1.39; 92.08)

0.0234

0.54

PENK

a

Sex

0.85

(0.49; 1.48)

0.5750

0.52

Age 60

3.88

(2.17; 6.92)

4.58 × 106

0.66

Age 65

4.14

(2.33; 7.33)

1.14 × 10 −6

0.67

Age 70

4.05

(2.04; 8.02)

6.06 × 105

0.62

  1. All variables are analysed by simple logistic regression comparing the pancreatic cancer group and control groups 1 + 2
  2. Italic values indicate the genes, where there is significant difference (p < 0.05) in hypermethylation frequency between the cancer group and control groups 1 + 2
  3. a VIM and PENK could not be evaluated by logistic regression because none of the patients in the control group had hypermethylation of the two genes; however, chi-square test found significant difference between the cancer group and the control groups 1 + 2. Despite that, VIM and PENK were excluded from the following analysis because only few cancer patients had VIM or PENK hypermethylation
  4. Control group 1; patients screened but negative for upper gastrointestinal malignancy
  5. Control group 3; patients with chronic pancreatitis
  6. OR odds ratio, CI confidential interval, AUC area under the receiver operating characteristic curve