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Table 2 Associations of birth weight-for-gestational age (BW/GA) with DNA methylation sitesa in venous umbilical cord blood at delivery, among 476 participants in Project Viva

From: Birth weight-for-gestational age is associated with DNA methylation at birth and in childhood

CpG sitea Difference in % methylation for 1-unit increment in BW/GA z-score (95% CI) Nominal p value Geneb Gene regionb chr
cg26663636 −0.39 (−0.52, −0.25) 4.31E−09 NOS1AP Body chr1
cg18181229 1.86 (1.16, 2.56) 1.80E−07 PBX1 Body chr1
cg06750897 1.93 (1.22, 2.64) 1.83E−07 PBX1 Body chr1
cg00222472 1.78 (1.12, 2.45) 2.03E−07 PBX1 Body chr1
cg20682146 1.54 (0.91, 2.17) 1.60E−06 PBX1 Body chr1
cg05780177 0.24 (0.14, 0.35) 2.39E−06 DENND1B TSS200 chr1
cg00325458 0.1 (0.06, 0.14) 7.27E−07 REL TSS200 chr2
cg23483765 0.22 (0.14, 0.31) 1.15E−07 NIPAL4 TSS200 chr5
cg24353833 0.42 (0.27, 0.57) 8.38E−08 NRM Body chr6
cg24641186 0.46 (0.27, 0.64) 1.41E−06 TFAP2B Body chr6
cg20392842 −1.58 (−2.24, −0.92) 2.54E−06 HLA-DMB TSS200 chr6
cg09364590 0.72 (0.42, 1.03) 3.66E−06 TIAM2 Body;TSS200 chr6
cg21809331 0.22 (0.13, 0.31) 2.28E−06 RBM28 TSS200 chr7
cg14731462 −0.92 (−1.29, −0.55) 4.20E−07 PTPRE 5′UTR chr10
cg25953130 −2.01 (−2.8, −1.22) 7.76E−07 ARID5B Body chr10
cg23890469 0.57 (0.34, 0.81) 1.55E−06 MMRN2 Body chr10
cg25124943 −0.92 (−1.31, −0.53) 2.34E−06 chr10
cg11606444 0.68 (0.39, 0.98) 4.28E−06 SORL1 Body chr11
cg01345517 0.15 (0.09, 0.21) 1.55E−06 DERA Body chr12
cg06648759 −1.08 (−1.52, −0.63) 2.02E−06 chr13
cg14276580 −0.94 (−1.33, −0.54) 2.24E−06 chr13
cg20549688 0.21 (0.13, 0.29) 3.20E−07 GTF2A2 TSS200 chr15
cg21842999 0.51 (0.3, 0.72) 3.20E−06 SHF Body chr15
cg09476997 1.81 (1.06, 2.57) 2.20E−06 SLC9A3R2 Body; chr16
cg27283514 1.51 (0.86, 2.16) 3.34E−06 chr16
cg19914554 0.73 (0.47, 0.98) 2.21E−08 CD7 1stExon;5′UTR chr17
cg20186396 0.73 (0.45, 1.02) 3.26E−07 CD7 TSS200 chr17
cg14909906 0.17 (0.1, 0.25) 2.37E−06 KDSR 1stExon;5′UTR chr18
cg23882285 0.12 (0.07, 0.17) 3.37E−06 ROCK1 TSS200 chr18
cg23026246 0.13 (0.08, 0.19) 2.23E−06 SPTBN4 Body chr19
cg23877608 0.17 (0.1, 0.24) 2.35E−06 CCDC114 TSS200 chr19
cg23344780 −0.58 (−0.83, −0.33) 4.10E−06 EMP3 5′UTR chr19
cg04803921 0.13 (0.08, 0.19) 1.68E−06 HM13 Body chr20
cg08422803 1.05 (0.69, 1.41) 8.04E−09 ITGB2 TSS200;5′UTR chr21
  1. Chr chromosome, UTR untranslated region, TSS transcription start site
  2. aCpGs are ordered according to chromosome number
  3. bGene and gene region information are according to annotation information from Illumina. Dashed lines indicate that the CpG is annotated to an intergenic region